ID G7YR16_CLOSI Unreviewed; 506 AA.
AC G7YR16;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Cathepsin D {ECO:0000313|EMBL:GAA55396.1};
GN ORFNames=CLF_107806 {ECO:0000313|EMBL:GAA55396.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA55396.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA55396.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA55396.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; DF144008; GAA55396.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YR16; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 256..506
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
SQ SEQUENCE 506 AA; 58210 MW; 69C0712B9309363E CRC64;
MKLRNSAIPG LDALFAVIRS TWSVIYFHRD PQTDQKNTCD LTSDSSYLCE LTWQTQKPRC
PQNCFFKPKH IKDDVRYGAF QKPKYVSAMM ARHRHTQFDN TPAANPLTVS SVDCLRLRTD
SCFSLNVILW SCLTVRHPSG ANKHYCFYYL TLSGCTVHTK ERHGFRQFIQ KHLLLLIPFE
DEDDVCTLHI DNVFVRYLKT GQYTTVRPRW TQDYPRSLLA VICHNSLPNL NYNDKPNGIN
QDLHERGCPP TQNSVYYGIV GIGTPPQYFK LLFDTGSSII WVVDQNRPRE LSMIKNAYIP
NDSETYVNTK REVTSPYGNY VATGHMAGDL VKLQSWQFLT YFSVVNKVQG HTDPLHLFDG
IFGLSAVQFL QNFDSTSLYD MVTQGLISRH MFAFVFRRGG VDGKLIFGEF SEEDIPEEVK
YVPLLDISVT GGHWMISTPM FPRILTVHLD ANAAQRKPHL TLPTVKVSID AVRRLWPRWN
LNPRYLKYET CFTSTRKRTL DASVSE
//
