ID   G7YTU1_CLOSI            Unreviewed;       992 AA.
AC   G7YTU1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Kanadaptin {ECO:0000313|EMBL:GAA56371.1};
GN   ORFNames=CLF_110728 {ECO:0000313|EMBL:GAA56371.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA56371.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA56371.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA56371.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DF144235; GAA56371.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7YTU1; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0016891; F:RNA endonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR   CDD; cd19856; DSRM_Kanadaptin; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR23308:SF53; KANADAPTIN-RELATED; 1.
DR   PANTHER; PTHR23308; NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT   DOMAIN          116..191
FT                   /note="FHA"
FT                   /evidence="ECO:0000259|PROSITE:PS50006"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          816..924
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          939..979
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          455..482
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        899..914
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        962..979
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   992 AA;  111126 MW;  F0D455EB741B0B98 CRC64;
     MSSSPTPIES NPCTEATPNE ESETPNTQNQ LSSPISECTG KDEVSDYLCE DKTQVFVQPK
     LQPAGNTYKP PVWAMPCPAD LGYRFEVIKN GTPLSECTVT LSEAGDSGDA TELSFCLFGR
     QPQPFYAPYN RLHGQCVALA HPSISRLHAV LQYGRPPPSI AKTSLAQPEA AGWYIQDLES
     THGTFVNKRR LPSGRFVRIH VGHVVRFGGS TRLNVLQGPE DDTERESTLS WTELKQVHFA
     KKAVAKERTV DKTPETTVDF GCDWGLAAED AAADVPSFLR DINGAACLSH ENLYQDDPKR
     ALRTYFEREG IDPAPEFEFV EASFGKQHCK IDLPLSSGTI TAEAIVAGKR KEAIAQCALE
     ACRLLDRLGE FDPNKDQSTA AKRIRTKAYW EEHDYYSSDE DTFTDRTGHV ERKRLSRIRQ
     LGVEGREAEE AERRAAEHAT ATCPYSAQRL DNATLLTVLA ELEKVGEEIV SLEEKLEKIN
     KEFTPQGQNP SELDELEAYM KALKSGQARV ILVMLIKPTV TSKIAAESFP GSLEHRIPGR
     TVAVLKCRRN VPAGPEHHLT RRVVRYQMKV SVRADREVWW TRKVKEMEEA QRASNARRLF
     QLIRVTGHRK PHRSIVPKSI FKPRRPVCLA AFNIGTLKPT GSLEHRIPGR TVAVLKCRRN
     VPAGPEHHLT RRVVRYQMKV SVRADREVWW TRKVKEMEEA QRASNARRLF QLIRVTGHRK
     PHTSARVRHL WRQSGISLDL KGGAPSRKER LKLRSQLFTL RQREMRLFQQ AGLPQPRQRV
     KLITTGGEEG EERVPVVEKT VRADAAAAVR AAKRKLQEDT GAADSHEVAP EQGPKNARLL
     RNEIKRSLAG HRTVQQSDRT RHVSEDQPFE VEEDDDEEVA APTEQSTLRD RPDPNSPAVP
     SETDLTTSNK DELESITGPK MPTEHRIDGV VVIEHKPAVE TASKPMGDNK GDLKSGHDSP
     DEHITASSPT QLSYSFCTNG RSNIRTSSII SL
//