ID G7YUR4_CLOSI Unreviewed; 399 AA.
AC G7YUR4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Beta-secretase 1 {ECO:0000313|EMBL:GAA56694.1};
DE Flags: Fragment;
GN ORFNames=CLF_111378 {ECO:0000313|EMBL:GAA56694.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA56694.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA56694.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA56694.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
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DR EMBL; DF144343; GAA56694.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YUR4; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47965; ASPARTYL PROTEASE-RELATED; 1.
DR PANTHER; PTHR47965:SF12; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 1..222
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GAA56694.1"
SQ SEQUENCE 399 AA; 45152 MW; AA996AB3237C5105 CRC64;
QSFSVIGSSP EEMNGLILIG GTNLTGMTQT VDTILYTPVR EPWFYEVVLT DLRVEEQSVV
EDCKELNVEF SIVDSGTTNI QVPERVFQPL LGHIKTYVAK QSSSTAAMLQ NYASFWTGAS
MLCETSSDNQ IGGATGLPYT LFPVIEFQML ALEADVNKKA LSLTLSPQQY IRFVGRHPKN
GVTRDCFAFG IRPHHSGTIL GAVFLEGFFT VFHRDSLKVG FGNSTCNRYS NVSTVTSSMV
NGVRAWKSSI GRKTPSECAF YRPVQLRITD KLDGLIHHRL RYCRFVNWIV NLRLHWENHE
ERKILVLSMA IGRHTSMPMR RTLERLQNPG VQIASDENLT DLEYADDIVL IFEEEEKAQV
FLDELTKVIP SFVFRSYGID FHLRNKMPVK NGKYGFLLL
//
