ID G7YVW6_CLOSI Unreviewed; 1628 AA.
AC G7YVW6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Spectrin beta chain brain 1 {ECO:0000313|EMBL:GAA57096.1};
GN ORFNames=CLF_112145 {ECO:0000313|EMBL:GAA57096.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA57096.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA57096.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA57096.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DF144539; GAA57096.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 71..243
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 259..367
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1131..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1628 AA; 188007 MW; 437DDAB0C52A3210 CRC64;
MTDTNVDISW DDLSLPVSTL YLTVMHPNSK NACALWMRAF TSRSRQRFGY ISDSTPCIIH
WHRQSLDERE YMQKVLFTKW INAQLGVSSA LDSMDSCSPI MDIQRAHPNH MARLWGLQEF
LCVRELFTDL RDGRVLIRLL EQLSGQYLII DNKVLVGEQD GNTKQEDRGS SRKDERAVVF
TLIFQSKPNT GQMRIHQLEN VNKALRFLYS QGAHLENLGA QDIVDGNPNL TLGLIWTIIL
HFQVQPVVVQ ESDETGEARH AKDALLLWCQ LKTAAYPEVD IVDFTSSWRD GLAFCALLHR
HHPEMIDFNQ MLTLDKEPEK RLEIVFNQAD DYLGIPKLIE PSDFAGGWWA DERCTLTVVV
TWYKWLNDSQ SAWRSANRLN HVLNQCVCSD RMISRYLVRA HRWLRWARSA TNRLDGIREM
VGNHETRDVY GMTGAEISIR VELQKMTDWR QGEKADKIEE RGQIEFLLHK IQVGQLAAAQ
VIFHPPVGYQ LSDIEAGSNE LSASEHNCHL AIITQLLRQA YLYHLRQRFD RKVEIFLSWL
DENQHLISVA EQTDLVHFRT DAKPIESFFQ STFADFVQTD VELHRFPVQS FQITTVCRKH
AAWIIDMDVY ADIHIQKLKL MIKELEFGWH SNENQERRLR WENLGERWSS LRERTKCRAD
ALNCMEKWYQ LLVEFQEMLK QVFFRVKQIN QYGAEQGTKV EVALENCEQD LLCSLKWGNS
AHTLIQLTEA EDFKIIGSPI MEELRDSVKR VVNWTEGMHC CLTSSVSRLR QWNAKRLQAL
QIKEDIEAYL YWIKDRECRC QLPSFEDIDP TNYNDIVLCA QHLRSQQRIL ENELILRYAA
KSDGAYSGSN QTFRDGIEDL HLVSCSSSPS LTDLSVCSIQ STEIIVDQLR QQEQKAICSG
EPLSMESLIE KYERQVDALK NNFGLDSDTM MDPPIEGSMM DKRSGECEPE CVFRLHLASA
AQLLGELYWN LAVVSKRVSE LWVKAKVYHE QLDLLEQLCE QNAAIDDMGR CLDQTYQNLD
LDLVCIQFDR MAKGLDEKIT SDSTDALDQH PMRISLDHEI TFNSQMRKLD HAIEKFMEFP
DLAKSVREKL LQYLASKSTV TQMDIEMDKL TWTRSGSQTF VEESLKDISS IHEVASEPKS
PNESDSDLEE EEEHAKNSED LIEPLGESPG TPKEKVTKTV GDVVEETDPL PQITVADEEH
VSLEHTCKEN TMDVVLDTKE QEDQLNSISC SVTSITEEQT GLGDFEREEV CPRPVPSPSD
IDLKLVLHPS LQLVSKALLT YVDLVQSKAQ RYLECCIVEK ERFSLKRDAL LLREKIAQLG
DWTDTMYDNL SSLLPELAPR AHGKLPFPTR QTEEDGEDMF VVEEDRTLVA KIYRFSLLLR
EIQASIKVVS EITKLDKRIY QAMSDMKGNN GYEELANFIV TTMGGIVLSE EEGPADFDLE
SERVVESDRL SDVEEKSTEK GIIHFKITED IQERWNKLQR LKESRQTRFD TAKAINTFYR
KIEQLNNQIA EKYIILLSTD ELGTDLNSLI QLQRKLFAWE EDMEHLSLGV EELRNQVEDL
QSRLRNEAPG RRDLRLISSE WLAAEEVERV FMDFETNWDE LQAALNERQE KLLISAELQH
FLQASQIY
//
