ID G7YWV9_CLOSI Unreviewed; 1552 AA.
AC G7YWV9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Lysine-specific demethylase 5C {ECO:0000313|EMBL:GAA57439.1};
DE Flags: Fragment;
GN ORFNames=CLF_112727 {ECO:0000313|EMBL:GAA57439.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA57439.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA57439.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA57439.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF144750; GAA57439.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR048615; KDM5_C-hel.
DR InterPro; IPR004198; Znf_C5HC2.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF133; LYSINE-SPECIFIC DEMETHYLASE LID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF21323; KDM5_C-hel; 1.
DR Pfam; PF02928; zf-C5HC2; 1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:GAA57439.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transferase {ECO:0000313|EMBL:GAA57439.1}.
FT DOMAIN 109..275
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 408..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GAA57439.1"
SQ SEQUENCE 1552 AA; 172807 MW; 782A4FA7C3AD363F CRC64;
PVRRGFNSCI ILFDSNAPLT YWRLNFTQSR KKVLTKGGRK SKTRETTAQD VPCSVVEQEF
WRIVQEYNDD IVVEYGADIH SSTQGSGFPT VDRLKNLVGT AQQLEDAKMY AVDPWNLNIL
PLLDRSVLRF IKGNIDGMKI PWCYVGMVFS SFCWHIEDHW SYSINFNHWG EPKTWYGVSR
LHAEDFERAM RKHAPDLFEQ APDLLHHITT NMNPNILQAE GVPVYRTDQY CGEFVVTFPR
AYHAGFNQGF NFAEAVNICL PDWLPIGRAC IDHYAVMKRH CVFSNEELLC TLAEVAVGRC
RPEDILLTTN SYHPNESSSK KCATKPRLPP GCSTAGLDIS AIATVHQEFT LLLNKERRLR
QLALNVGVVR MEKVRFDELW DDVRVCDACS TTLFLSGISC PCASFVASPK KTSPRGDQPS
GAVGRKRRAS DGPVEQERTE EHDVSFEENQ RTRRFMVCLQ HFDELCPNCE PSACTLKYHY
TIEELEDLER ALARCSNAFY DWRRPLLQLL SNSNWNSTSF QTDKQEPPTD LIEPKPDCSP
SISQDAPPDR CIMTLEELQN HLNVGRTAGY HVDEVFTQVQ ALCERANKLL SICASVKSAL
TSSRDSELDG ENKREVDDQQ ADSPSTLGFL LRLPTVSSLP STAESSKQHN PSVSLHHEID
LNNIRELDLS RLMEACKQQY PINLMTEPDV WFVQDVLNFL NVWRQSAREA VGAVCRLTLP
TATRSLTTHC PSNLTSPLLV DVSAITSLAS SNAHTSPNDE AALLLLSDVV KSLSDKYPRL
AGRLPDWNSL NLLHDAFKWM CVFLRQTDEQ QQSLWTYPRL RQHLHQGENL VLQLNSLSST
PSTKSPGKTT PTLSARSSLN SPSSSPSLSI DLLSAPVPRI LRARMRTSVA QLSQSAMQVE
SLVGVLTELL GLPGSFSCPE VLIVLGQIQT LRVSHLTQWD SPVQDKSGNC TPEPSLQSNQ
ENKTARLDKE LVQHYLPETA EKVSSLMSPL CSLLSGRIRG LLSSVATSEV ASRPQLVEAE
VLLAIGLLLD TLPVDTPTSE SPETESPGGL SANMKQLNSL ISATRTASSR LWEAFLAARS
NDQSDNAPLV RHLLPKFPLD TDNDTCFYEF MDAYAKSPPD AVVRTLSASV YRIIVVANNN
ISLRTLVLSC CVTTDTRDES TGMGNPSGIA SVPKRLTGYE VVADCPKFGH MKLGRNIGRY
SLINQPMVLV HRSYRPECVA FQFAKLTVLS FKEKLLRTEL AFQNGYLTSG HLEVYTIQTQ
KSRKCLTDLL EAFANDRRAC SSCSERLALR TTEVDVWRIP HKIQVHLCDV DGVLNNILRT
SEGNSDMPFQ NPEVLECLEH HDARSPLARL DHLTNVHTAT FWLSGLTGDA ADPTGKCLFC
PLFPDQSNCA SQDRLAQLNT LWALTSTDNS KTKPLCTPQA VVYHAFTKQF DAWLAELSEL
LRAHAVTLAG AWVKLDVTKP VNLPAPVQSV VDTITSLQHV TAGSNVDSLT IQYTGRTGTL
RLGDVASQTL SLTGAALHQL SYSHPRGLDF RPNHSSLLVR TMHLNVVSES IV
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