ID G8B5F4_CANPC Unreviewed; 431 AA.
AC G8B5F4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=Alpha-1,6-mannosyltransferase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_602650 {ECO:0000313|CGD:CAL0000149163,
GN ECO:0000313|EMBL:CCE39846.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE39846.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the glycosyltransferase 32 family.
CC {ECO:0000256|ARBA:ARBA00009003}.
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DR EMBL; HE605202; CCE39846.1; -; Genomic_DNA.
DR AlphaFoldDB; G8B5F4; -.
DR STRING; 578454.G8B5F4; -.
DR EnsemblFungi; CPAR2_602650-T; CPAR2_602650-T-p1; CPAR2_602650.
DR CGD; CAL0000149163; CPAR2_602650.
DR VEuPathDB; FungiDB:CPAR2_602650; -.
DR eggNOG; ENOG502QW2I; Eukaryota.
DR Proteomes; UP000005221; Chromosome 6.
DR GO; GO:0000136; C:mannan polymerase complex; IEA:EnsemblFungi.
DR GO; GO:0000009; F:alpha-1,6-mannosyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR Gene3D; 3.90.550.20; -; 1.
DR InterPro; IPR007577; GlycoTrfase_DXD_sugar-bd_CS.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR039367; Och1-like.
DR PANTHER; PTHR31834:SF11; GLYCOSYLTRANSFERASE HOC1-RELATED; 1.
DR PANTHER; PTHR31834; INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE; 1.
DR Pfam; PF04488; Gly_transf_sug; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..126
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 431 AA; 48952 MW; 332ED7069F8B6892 CRC64;
MRSLYRSASK LELHSDPPPV SHMPKYQTSS NNRGRKILIG TVLVSLVIIT VAFFSGSLTP
AKDLQGVISS LPNDKLLGLS NFLSSENSKN QDELLSKIEK LNKKLFQAQE AKINKLEEQN
KLILQELKLL KTPPSSASIR DKLTYLYPFN SESKFPAYIW QSWKHGLNDE RFDDKFRQGE
SQWAFKNPGF VHELFNDDTA HTVIKYLYSQ IPEVIETFEL LPEIIMKMDF FKYLILYAKG
GVYADIDTYP LQPIPNWTPE NVSPLDIGMI IAIESDSSSP DWRKEQIRRL QFGQFVIQAK
PGHPILREAI AQIIEQTKVK KLESLAASGG GGPLRLIGNT NEKSLKISQW TGSAIWTDVV
LKYFNDYIQS SVFQKVTWKE FHKLQTPKLV SDVLVLPVKS FASDVEVSKD GKIEDPLAFV
KHYAAKIWKS G
//
