ID G8B5S0_CANPC Unreviewed; 1499 AA.
AC G8B5S0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
GN OrderedLocusNames=CPAR2_603800 {ECO:0000313|CGD:CAL0000151321,
GN ECO:0000313|EMBL:CCE39962.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE39962.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HE605202; CCE39962.1; -; Genomic_DNA.
DR STRING; 578454.G8B5S0; -.
DR EnsemblFungi; CPAR2_603800-T; CPAR2_603800-T-p1; CPAR2_603800.
DR CGD; CAL0000151321; CPAR2_603800.
DR VEuPathDB; FungiDB:CPAR2_603800; -.
DR eggNOG; KOG0065; Eukaryota.
DR Proteomes; UP000005221; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR005285; Drug-R_PDR/CDR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR NCBIfam; TIGR00956; 3a01205; 1.
DR PANTHER; PTHR19241; ATP-BINDING CASSETTE TRANSPORTER; 1.
DR PANTHER; PTHR19241:SF625; ATP-DEPENDENT PERMEASE PDR10-RELATED; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 508..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1192..1212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1224..1243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1263..1291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1312..1336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1342..1360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1461..1482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..398
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 855..1099
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1499 AA; 170349 MW; 7ECB7A306B1EC1A1 CRC64;
MTEFETELEG DPKSKLEKQK TPSSSSGSSI HEFSGFDALE VQEIARTYTN EDTSSATKLR
RYLTHMSQVP GVNSAEEIED ERLDPNSEYF EAKFWVKNQK KLFETHPDYY KPSRLGVGYR
NLRAYGTAND NDYQPTVTNG LWKYATEALS MLKKEDESKM FNILKHMDAI MRPGELTVVL
GRPGAGCSTL LKTIAVNTYG FHLGKESKIT YDGLTPKEIA KHYRGDVIYS AETDVHFPHL
SVGDTLQFAA RMRTPQNRGE NVDREKYAEH MADVYMATYG LLHTKNTNVG NDFVRGVSGG
ERKRVSIAEA SLNGANIQCW DNATRGLDSA TALEFIRALK TSAAVLDTTP LIAIYQCSQD
AYDLFDKVVV LYEGYQIFFG RADKAKEFFV NMGWDCPQRQ TTADFLTSLS NPSERKPRPG
FENKVPRTAE EFEARWKNSL EYAALIEEID EYFAECDNLN TKQLYHESHT ARQSDHIRPA
SPYTVSFGLQ VKYLMYRNWL RTKGDPSITL FSIFGQLVMG LILSSMFYNM KSDTKSFYWR
GASLFLAVLF NAFSSLLEIL ALFDARPIVE KHKKFALYRP SADALASVIT ELPTKFFMSM
SFNIVFYFMV NFRRDAGRFF FYWLMCIMCT LVMSHMFRSI GAVSNSIAEA MTPATVILSA
MIIFTGFVIP TPKMLGWSRW INYINPVGYV FESLMVNEFH NRDFSCAEFV PSGANYQNAR
NANRVCSAVG SIPGSDVVDG TDYLKLSYEY YNAHKWRNWG ITVGFVVFFL FVYIALTEFN
KGAMQKGEIV LFLRGSLKKR KQKRMEEAHD SEFGGMPNEK VSREAEGEAA RFEKTGNADE
GSVGSTEIPS NREIFFWKDL TYQVKIKSED RVILDHVDGW VKPGQITALM GASGAGKTTL
LNCLSERVTT GVITDGTRLV NGHSLDSSFQ RSIGYVQQQD LHLPTSTVRE ALQFSAYLRQ
SNKISKKEKD EYVDYIIDLL EMTSYGDALV GVAGEGLNVE QRKRLTIGVE LVAKPKLLLF
LDEPTSGLDS QTAWSICKLM RKLADHGQAI LCTIHQPSAL LLQEFDRLLF LQRGGKTVYF
GDLGKDFKTL INYFEKNGAD PCPPEANPAE WMLQVVGAAP GSHAKHDYFE VWRNSQEYQD
VRKEIATMET ELSKLPRDED PEAKYTYAAP LWKQYLIVTW RTIVQDWRTP EYIYAKAFLV
ISSALFNGFS FFKADRTQQG LQNQMFSVFM FFVPFNTMVQ QLLPQFVKQR DVYEVREAPS
RTFSWFAFIT SQLTAEMPYQ ILVGTIAYFC WYYPLGYYAN AEPTNAVDQR GVLMWLFINC
FYVYTSTMAL LCMSFMELAD NAANLATLLF TMCLNFCGVL KTGEEMPRFW IFMYRCNPFT
YLVQGMLATG LANTSAKCSS TELLTVDPPN GQSCSSYLKS YAEEAGGYIV ETNGCQYCTI
KDTNTFLASI NARYSERWRN FGLVICFIAV NIVFTALLYW IARVPKGNRE KEGKKKSEK
//
