ID G8B6Q9_CANPC Unreviewed; 846 AA.
AC G8B6Q9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=Magnesium transporter ALR1 {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_101790 {ECO:0000313|CGD:CAL0000145631,
GN ECO:0000313|EMBL:CCE40141.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE40141.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765}.
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DR EMBL; HE605203; CCE40141.1; -; Genomic_DNA.
DR AlphaFoldDB; G8B6Q9; -.
DR STRING; 578454.G8B6Q9; -.
DR EnsemblFungi; CPAR2_101790-T; CPAR2_101790-T-p1; CPAR2_101790.
DR CGD; CAL0000145631; CPAR2_101790.
DR VEuPathDB; FungiDB:CPAR2_101790; -.
DR eggNOG; ENOG502QPTQ; Eukaryota.
DR Proteomes; UP000005221; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR CDD; cd12829; Alr1p-like; 1.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR044089; Alr1-like.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR PANTHER; PTHR21535:SF55; MAGNESIUM TRANSPORTER ALR1-RELATED; 1.
DR Pfam; PF01544; CorA; 2.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 748..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 94446 MW; 2B2D75F2ADEF8DAA CRC64;
MSDTESVFQP TGNNHNTLRT DEILNDHRNQ DTSVGSAIID DGDDHLDPVG VSSQDNPRSK
GRTSSKAESD LGEGNNPDAI SNPATSGRRK STRRTSARRQ SIGEGALPSQ FQSYNQSQPN
RSYMASLRKD FYLEDDEDNT ALPVPIINNP TNSGKPRSKS TIETLAPIIK KKTHRSNSNN
LEADISSPLT KIKTNDSFII TSNGNGEEVK IRRPSKSSID SEADSHGSRS SQETEEDVCF
PMMREHVKVN GIDFDEIDEF IREEREEAAM QREFLTRNQS AIEEISYENS RKFDNLRRSG
SANAIPSNTS GLSRQPTSTA ALKYTPKNIL HKTFQRSNEV PESTSTTSSS LEELKARQAV
GADDASSMEQ VKFGGARVTD GTNGTLPDRF SFFHSESEET VHAPDIPSLV PNGESIQELF
HNGEETWWLD CTCPTDAEMK MLAKAFGIHP LTAEDIRMQE TREKVELFKS YYFVCFHTFE
ADKESEDYLE PINVYIVVFR DGILTFHFSP LTHPASVRRR VRQLRDYVDV TADWLCYAMI
DDITDSFAPV IHGIEYEADA IEDAVFTARD TDFSNMLQRI GESRRKVMTL MRLLSGKADV
IKMFAKRCQD EAALGYEKQQ QQQRRQQRLH QDYASPRSSS ANIPETHGSG GGGGGGGNTP
SNNSTGHNGM PSSFGQSQAW SQNMADNARP RADIALYLGD IQDHIITMFQ NLLAYEKIFS
RSHSNYLAQL QVESFNSNNK ITEMFSKVTI IGTMLVPLNL VTGLFGMNVT VPGQDSSIAW
FFGIVGVLIL VVIGSIAFAN WWLKSINRQI DKEKRAGFSS SRRSIRSLGL RRHSAKSVIS
FPNKYD
//
