ID G8B8S2_CANPC Unreviewed; 704 AA.
AC G8B8S2;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JUN-2023, entry version 36.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN OrderedLocusNames=CPAR2_300100 {ECO:0000313|CGD:CAL0000148319,
GN ECO:0000313|EMBL:CCE41021.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE41021.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE605204; CCE41021.1; -; Genomic_DNA.
DR AlphaFoldDB; G8B8S2; -.
DR STRING; 578454.G8B8S2; -.
DR EnsemblFungi; CPAR2_300100-T; CPAR2_300100-T-p1; CPAR2_300100.
DR CGD; CAL0000148319; CPAR2_300100.
DR VEuPathDB; FungiDB:CPAR2_300100; -.
DR eggNOG; KOG2710; Eukaryota.
DR Proteomes; UP000005221; Chromosome 3.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 172..531
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 32..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 78730 MW; 9248D838A2BEB144 CRC64;
MSHSQSPNNR GSIFGWAKSL KRSNLLSNES VNEISDNDSI SRSPTKGGYI SPHQQHSPLN
IPNAHAHNSH MNSDSQNSFS SYQNQNQNQH QLHQNHQIQN HGGNFFGSSP AGSSHHSDFL
RPLLNHKSRS TNNVSRVRSN SLNQSESSIR QHRDSFMQTN ALVDENSKYF GVPLQQALNE
ASAKISILTG DQSDGLQYGQ IPIVVAKCGV FLKKNGLTVE GIFRVGGSSK RIKDLQVIFN
TPPSFGKQLN WDGYTVHDAA SILRRYLNAL PEPLIPLNMY DDFREPLRNR KRIISYMQYK
AENPSKSLKQ ASLEDVTNSS QMLTEANVEK FNDNNTGFEF RERNVSTISS HPTSSIQPTT
EQEQQQQQPQ QQQEQQQQRQ PQPPPSQRQQ QQQQQQQQQQ QQQQQLQEQS QPQPSQHVSS
RQPTDEEIEL KNKKKSKNYK KLTRDVHAAI DDYKHLVNDL PIASKQLLFY VLDLLAMVRN
HSKENLMSSR NLAAIFQPSI LSHPNHDLDP DEYALSQLVV EFLIHYAYKL LPTHTPKSTT
IGTNEDVVAI EPPHAPQSTV TSTSTTPLES ATSLSKNDLS SKEPVVSAQP APPPFNRRYS
KSLSSAGNHE DLVVGYQHNV TGSIPFESDV DYEISDENDI GSDVEESYFH SSRLANAASP
TRSNFDDEVS GAQPKVSNNG TTEEPVIIVT TPSSGPTANT AKVD
//
