ID G8B9C1_CANPC Unreviewed; 2359 AA.
AC G8B9C1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JUN-2023, entry version 37.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN OrderedLocusNames=CPAR2_302100 {ECO:0000313|CGD:CAL0000147807,
GN ECO:0000313|EMBL:CCE41221.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE41221.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
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DR EMBL; HE605204; CCE41221.1; -; Genomic_DNA.
DR STRING; 578454.G8B9C1; -.
DR EnsemblFungi; CPAR2_302100-T; CPAR2_302100-T-p1; CPAR2_302100.
DR CGD; CAL0000147807; CPAR2_302100.
DR VEuPathDB; FungiDB:CPAR2_302100; -.
DR eggNOG; ENOG502QRR7; Eukaryota.
DR Proteomes; UP000005221; Chromosome 3.
DR GO; GO:0005938; C:cell cortex; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032065; P:maintenance of protein location in cell cortex; IEA:InterPro.
DR CDD; cd13365; PH_PLC_plant-like; 1.
DR InterPro; IPR024774; PH_dom-Mcp5-type.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR28190; NUCLEAR MIGRATION PROTEIN NUM1; 1.
DR PANTHER; PTHR28190:SF1; NUCLEAR MIGRATION PROTEIN NUM1; 1.
DR Pfam; PF12814; Mcp5_PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 2158..2271
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1804..1839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1896..1915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2096..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2310..2359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 113..263
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2315..2333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2359 AA; 265992 MW; BCE5399887F14E94 CRC64;
MSSSDKSSKD DIRSQLSDMQ KRLFSKKSSS SHHDAFKEST SFNSSQLPHQ HPLFQHHDQE
NALATLSHPE RRSGDELPLP TIKRSKKADK LHSSLPLGAE SKGNDMNFVV GLSENLLTEC
RRLNADNTKL KSKLKQALQE VQTLKEETGK LSNSNQTYIS NESELKDKNW QLESQISSLK
EDIKILEKSN DKLKVLQEDM SGQLNQITKN NDELDITNSL LSKKLKDLET KYEKDTKELS
ERVENLNDEN DNLQSKLAAT TVVEPDAGTE GAIKTFKEAQ NAPDANSGVY VSGLESILKE
LEQFQGTNNG SKMATIDNAI SRLRDHIDKV SSGDSNTRSL KHTQSTPSKS EEEVYASSEF
PLSKALAVSH ANSVSEPSVN SDAGWDQFLG QNVERTPSKP KHGDIIQQFD GDEVADQSYH
LNISVEGSPT TMEQTTPHKN KHSVEDVFQL IDTLLKSDEQ DRKFRDLFES RGMKLLSTVE
YQKLVDHAKT IEPIIEETPA VSKTKLMELD QNARSLNRPD LKYLTDHAKQ LGYVVIDSEK
YNKLNGFGKN PSIDYLVKKA KEHNKVLISN DELDNILNPN EEQIKTHAEK LHLKVFTESE
VAALKTPPLS AVKSLASEHD HVLVSSDEHS TTHKMIDSPT LDYLKKHLDT HEHTSMSNKE
LQELLERAKN PSVDEVKQHA HKRGLTALPK EEHEKLSFLA HNPSLGHIEQ CAEKMGYAVV
ERKSWDTLNT MSSDPPVTHI RDLATKNKMM LLPASEYDEL KRLSSQPDME HIKKAAAKMK
YSVITNDNYE ELKRRVEDPS VEELESAAQK KNYKMVTNDD YSSIIKRADE PDLEHIKEAA
TKMKYSVITN DNYEELKRRV EDPSVEELES AAQKKNYKMI TNDDYSSIIK RADEPDLEHI
KEAATKMKYS VITNDNYEEL KRRVEDPSVE ELESAAQKKN YKMVTNDDYS SIIKRADEPD
LEHIRHASSK LDYRVVSNSD FEELQRRVNE PTIEEISSRA TKLGVVVVGG EVYQRLCSPS
VQDLQAHCDK LQLHLCPRTE FEEISDKLDN PKMDYLVECA EKHQSTVINN KELAILKEKA
NEPDLAHLEE KSRLRNHVIV PEDRFKLMER QISNPSVEEL KSLAKSIDYV VLDEQEFNKL
KNPSRSMLEK SAAVYGCSFV TTDELERLKQ HEKAPTKEFI VSKASEKGLV VIPKKEYDEL
NVDANNPSKE HLAQKAKEIG FVAIPMRDHE SSRSQLDNPT IDFLREKAKL YDQDLISSST
LAAMQECVSN PSLEFLNEKV ANYNSTVVDT KRYNELVELD ISPNAEKLKE KAHEIGCDVV
EQEELVELRR IRDDPNVDDV SRMAAALELA VLSESERDEL SHCIESPTVD YLKEHANKLN
YTMIETPVYD ELKVFVESPS KEFITEKAHS AGLAAVPEEE YLLLCHRAND PDLDELMAQA
KTKKMTLINI DELEKLHSQL TDPNIEYLSQ HVEEAGCVMM TKEELATMKL QVESPTDEYL
KEKCGKLKLA TLPESELINL RSMVESPSVG FLTEKAEAQD YKVIKNSDYL AMVRNIESPD
LEYLKLHAGS KEMQLIGVSD LASLHSRIEN PSREYLSEHA EKVDNVMVSK DEIAALKLQV
ESPTDEYLKE KCGKLKLATL PESELINLRS MVESPSVDFL AEKAEAQDYK VIKNSDYLAM
VRNIESPDLE YLKSRAGHLD SVLISDSEHK ALLEPDRASI EASALALGLA TIPQADLEKL
KEISDAPDLV YLKAKAESLG YELIQCEDLA TLHTTIDNPR KEFLQQKADS LGCVIISKTE
LDQLRSTTSR PEANTGTRGA SKSENPTALA DEEAQSRTKL SHELCAAHDD DSAVRKMREF
LNDRGYTIIP IAVSRSSSNT TNSNEYDDAG NSFEATRNQQ SQTNAEDSTK NHHQLQRTIS
ENTLANAANS RSLSLVPDSE FISLKKDRLG KERLEKRVKE VVNELYGLKS ALVEKKDVIR
SLESEVLQFE CPVSKEHIRS CATDLGLLCI SATYYVGTTT HPRPDVDHVK ILPASYFNQL
LKYKSSSVEK ISNDAFERFA KKRGYVKKDL GAPDMALVQP GSGIDAKFSP PSHTLVRGGQ
DGTHTPPVVP IQRHLPHSSS LRSNLSEFST TSLRSTGMFS MATDVSFTDK SMIPAITQVV
IGEYLFKYYR RFGSAFSAIA ETRHERYFWV HPYSLTLYWS ESNPVLSNPA SRKTRAAAIV
DVDSVEDNNP IPTGLYHKSI IVRSTDRSIK ITCATRQRHN IWYNALRYLI HRNIDDLSVD
MEGGEDGDAD VDTDDDIDAS PISHMMQIPK STSHKNLDAL RDTGDRRAFP RPKRISSQEG
IKTPRTPGGV SRLSSFRRS
//
