ID G8BA28_CANPC Unreviewed; 227 AA.
AC G8BA28;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 18-JUN-2025, entry version 48.
DE RecName: Full=Thymidylate kinase {ECO:0000256|ARBA:ARBA00017144};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN OrderedLocusNames=CPAR2_804510 {ECO:0000313|CGD:CAL0000149473,
GN ECO:0000313|EMBL:CCE41901.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE41901.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
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DR EMBL; HE605205; CCE41901.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BA28; -.
DR STRING; 578454.G8BA28; -.
DR CGD; CAL0000149473; CPAR2_804510.
DR VEuPathDB; FungiDB:CPAR2_804510; -.
DR eggNOG; KOG3327; Eukaryota.
DR Proteomes; UP000005221; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:dTMP kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EnsemblFungi.
DR GO; GO:0009041; F:UMP/dUMP kinase activity; IEA:EnsemblFungi.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006227; P:dUDP biosynthetic process; IEA:EnsemblFungi.
DR CDD; cd01672; TMPK; 1.
DR FunFam; 3.40.50.300:FF:001633; Thymidylate kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..108
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 227 AA; 25591 MW; 4C455C08FBB3F7C5 CRC64;
MLRGQLILIE GLDRSGKSTQ ASILASRFTQ SKLIKFPERS TAIGQLINEY LTNKQFQLSD
QSAHLLFSAN RWELNQEILN LLHQGYFVIL DRYIYSGIAY TLAKHKDMET TGATEATSVD
SSTNLSNVEW LLAPDKGLPK PDLTMFLTLD MDEISSRKGW GDERYEMVEF QSRVKQCFLE
VLDDASDPSV RIVDVGKKSI EQVADLLWNV VESSKANVLT DKSIGHV
//
