ID G8BCG4_CANPC Unreviewed; 1270 AA.
AC G8BCG4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_803790 {ECO:0000313|CGD:CAL0000147897,
GN ECO:0000313|EMBL:CCE41829.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE41829.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
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DR EMBL; HE605205; CCE41829.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BCG4; -.
DR STRING; 578454.G8BCG4; -.
DR EnsemblFungi; CPAR2_803790-T; CPAR2_803790-T-p1; CPAR2_803790.
DR CGD; CAL0000147897; CPAR2_803790.
DR VEuPathDB; FungiDB:CPAR2_803790; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG2421; Eukaryota.
DR Proteomes; UP000005221; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:EnsemblFungi.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; IEA:EnsemblFungi.
DR CDD; cd14483; SPX_PHO81_NUC-2_like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR030395; GP_PDE_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR23206:SF7; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF03105; SPX; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS51704; GP_PDE; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..191
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REPEAT 485..517
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 561..593
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 595..627
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 912..1268
FT /note="GP-PDE"
FT /evidence="ECO:0000259|PROSITE:PS51704"
FT REGION 244..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 143398 MW; D68AB07DAD29A46B CRC64;
MKFGKYLASR QLELPEYSGH FIDYKALKKL IKQLAIPTNK TNGNTVSSVI AGNSNSSISE
IQQSLKENKA TFFFRVEREL DKVNSFYLEK QANLAINLNL LVLKRDELFT KSHAFLLQHS
HDGTTANVDS AAYLNFRNSI SFLNLYQNFK KIHQDLIRLQ QFIELNETGF SKVVKKWDKR
SKSHTKELFI STAVSVQPVF HKNEINELSD LVTSSLFDIE SIMDGDYSCL VNYNAHSTIS
SSIESDSVQR DIAPPSASGS ASDIVSNSPA SHNNHAPPFI RQTSISISPN SNTEVDELYS
SFVNVATIKD PDLSLLARWV EKLNGSPKLA NEPFDATVRY KASKIFLLSI TNLKISDSFL
ESFLKLINFD IDFTFVNDDF NNNKTVFHEC CSMPPASTHN ESHHVVINNG VKVINSNDSI
NHSRVFIVEY IMKTYSPQEV SNLLKRRDFN GRTCLHYAAQ NNRSDLLDII IPAFPTTHID
DLDNDSMSPL LLAIKHGHLN IIKNLVQFGS NPFPRTNKET LQYLPINYAC KFGDYKVLEY
LLSNEESSDL VKVLVNEQDV EGLLPLHVVA REGHYKLITL LIKYGAEVNK TDGFNKWTPI
FYAAAEGHVK TTQELVKFGA KLDILDEDGY NVLYYCVVEG HVGVINELLS YHQDMNTELD
NHSNVESGKI MSIQGDPIRM SDDNDDSEDS GQSIDKNNAD SIPDLQLPPP ILPLRRYGHN
FLEQKVLIEL IFPHDDQSFI NLFNSITDLK PGRITLTSNI SDIVPRNILL PLEDKNHHGG
ANNNNCVFQT DVDSLNEFRI DFEIFPKFGT RLIAKTTALS FSHIDTTSPE ISSIELPLFD
LRLRNIGQLK FNYQIIFPFS GTVLETTKFD TYWKSSTSII KNKQTLKLNA AGGLSPNNFL
SPNANAAVNA SGLNHGPNAR PVQVQQEYLS SSSSIVTATS LSGEYLRIRV CLLNDGTPVV
CPHWSIAITE TIDLYLPNLS LEQLSSITND LFDYSKVIHD LSNMTVKDIG LIKKLLRIIY
LPLDIVLEIL SPEININLEL IFPSFYELEV LPFVGNIQKN LNNYIDFTLN DVFNHIKPFK
SKENQHNHNN HHQSSRSIIL LSSNSLICKI LNWKQPNFPV FLIMNGITYN NNFKKFEQRS
TNGLLIDEGK DQQNKVSNKY STTTSPSLSS STELNNYQEL IIRSIKEAVN FTMNNNLFGL
ITSIHLLDLV PKLIPLIRSR GLILVASSDT NDQDDAEEEV LKRELDSYTK TEINGLRFDD
VLSFKQDITM
//
