ID G8BE49_CANPC Unreviewed; 545 AA.
AC G8BE49;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Pyridoxamine kinase/Phosphomethylpyrimidine kinase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_211900 {ECO:0000313|CGD:CAL0000153425,
GN ECO:0000313|EMBL:CCE43546.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE43546.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
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DR EMBL; HE605206; CCE43546.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BE49; -.
DR STRING; 578454.G8BE49; -.
DR EnsemblFungi; CPAR2_211900-T; CPAR2_211900-T-p1; CPAR2_211900.
DR CGD; CAL0000153425; CPAR2_211900.
DR VEuPathDB; FungiDB:CPAR2_211900; -.
DR eggNOG; KOG2598; Eukaryota.
DR Proteomes; UP000005221; Chromosome 2.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR CDD; cd19367; TenA_C_ScTHI20-like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 1.20.910.10; Heme oxygenase-like; 1.
DR InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR004305; Thiaminase-2/PQQC.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF03070; TENA_THI-4; 1.
DR SUPFAM; SSF48613; Heme oxygenase-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 28..292
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
FT DOMAIN 328..540
FT /note="Thiaminase-2/PQQC"
FT /evidence="ECO:0000259|Pfam:PF03070"
SQ SEQUENCE 545 AA; 60538 MW; 30095F25386BDF14 CRC64;
METKDVKLKN PRAKDVALPV VMTIAGSDSS GGAGIEADLK TFSAFGVYGA TCITALTAQN
TTGVKLFEKT SQKLLAEILK ANLEDFYGYE NAPLKVVKTG MLTKQAIEEI AKHDIKVKFV
IDPVMVSTSG SQLFDLDGIK YSVEHLMKNA YLITPNLPEA KALYGLFKSP SEIGNIEDFK
RFVVELSNLL KCKNLLVKGG HIPFDQEGNF SKNGCQVIDI LYESESQIVT LFSSGYINSE
NTHGTGCTLA SAIAANIAIG KTLADAIAVA IDFIHNGMSQ MTKLGHGNGP LNHNLTPNIQ
VTRVIETDGN ELLKFDDANT FVDFLTSHPK VKQTWRNYVE HPFVSKLAEN SLPFENFFYY
LKQDYHYLII YARMHGLLAS KAPTYQQTHA AATIIGEIIN EIEHHKKRLK VYKVDYERDI
EDLKPGNACV EYCDYLINIG EKEDFLGIKV ALAPCLHGYA EAGTYGKKLR AENPVKIPEV
YQGWLDEYAS DWYSKADKEG RLALNALVAD GITRPRAEEL VDIFNTVSQL EINFWNEVLD
MSTCV
//
