ID G8BE77_CANPC Unreviewed; 1311 AA.
AC G8BE77;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE RecName: Full=5-oxoprolinase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_212180 {ECO:0000313|CGD:CAL0000155923,
GN ECO:0000313|EMBL:CCE43574.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE43574.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the oxoprolinase family.
CC {ECO:0000256|ARBA:ARBA00010403}.
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DR EMBL; HE605206; CCE43574.1; -; Genomic_DNA.
DR STRING; 578454.G8BE77; -.
DR EnsemblFungi; CPAR2_212180-T; CPAR2_212180-T-p1; CPAR2_212180.
DR CGD; CAL0000155923; CPAR2_212180.
DR VEuPathDB; FungiDB:CPAR2_212180; -.
DR eggNOG; KOG1939; Eukaryota.
DR Proteomes; UP000005221; Chromosome 2.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR InterPro; IPR008040; Hydant_A_N.
DR InterPro; IPR002821; Hydantoinase_A.
DR InterPro; IPR003692; Hydantoinase_B.
DR InterPro; IPR045079; Oxoprolinase_fam.
DR PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR Pfam; PF05378; Hydant_A_N; 1.
DR Pfam; PF01968; Hydantoinase_A; 1.
DR Pfam; PF02538; Hydantoinase_B; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 8..221
FT /note="Hydantoinase/oxoprolinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05378"
FT DOMAIN 239..537
FT /note="Hydantoinase A/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF01968"
FT DOMAIN 740..1266
FT /note="Hydantoinase B/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF02538"
SQ SEQUENCE 1311 AA; 142517 MW; 8153E0E469CFF944 CRC64;
MTIQGIQIAI DRGGTFCDVI AKIPGQEDYV FKLLSVDPQN YKDAPTEGIR RVLEHVNRVS
ISKSAKLKLD QIQSIRMGTT VATNALLERK GANVLLVTTT GFKDVLVIGN QTRPHIFDLT
AKKLGHLYKQ VLEIDERVTI EGFSEGGGDK LLIDKSQPNL TEGVTGDTIR IIKEPNYAQV
EKDFREIYNQ GEIKAIALSL LHAYAYPKHE AEIAKIAKKI GFEVSVSHEL QPMIGFVNRT
SSTVADAYLS PVINEYIQNF GSGFEGGLDA FGNKLLFMQS NGGLCPWYKF TGLKAILSGP
AGGMVGFGET CYDETSRKAT IGFDAGGTST DVSRYDGQYE HIHETIVSEI NLQTPQLDIS
TVAAGGGSIL FWKNDLFVTG PESAGSDPGP ACYRKGGPLT VTDANLYLGR LVPEHFPKIF
GPNHDQGLDY EIVDQKFKEL TQQINKDQAS KGIKLKPVEV ASGFLKVAVE SMARPIRNMT
EAKGHETSNH NLACFGGSGG QFAVSLAKNL GITSVAVHKY SSLLSAYGIQ LADIVIEKQS
PASITYAKEN LSALDSKIEL LIAAAQEDYQ KQNLTDFSTR LDILLNMRYV GSDTHLLIPT
KVGESDAAEK FIKRHRNEFG FNLDREVLVS DVEVMLIVES KDKEEHNPYQ EAAQLSSTLE
PPTTSFTKPV YFETFGWLDS PVHLLPDLPK GALVKGPAVI IDNTQTLIIE PRSRARILAH
HVLIEVEQEE KPQLSSTTVD PIQLSVFGHR FMSVAEQMGR TLQQTAISTN IKERLDFSCA
IFDHNGDLIA NAPHIPIHLG SMSYAVKAQI KMWEGKLEPG DVLVSNHPIA GGSHLPDITV
ITPVLDEHNE PIFWTASRGH HADIGSIAAG SMPPNSKTIY DEGAAIVTHK LCVRGKFDEE
GITKILVDEP AKYPGGSGTR TLSDNLSDLK AQVAANYKGI VLLQRLVDDF TYEVVKLYMG
GIQSTAEVAV RNLLKLAYEK FGSHELKGID YIDDGTPIAL TVTINPETGS ALFDFSETGD
EIYGNLNAPT AILYSAVLYV LRCLISTDIP LNNGCLRPIE FKTRQGSLVA PSDDAAVVGG
NVETTQRIVD VMLKTFQAAA GSQGTCNNFT FGINDKENGV CFGYYETICG GAGAGPDWDG
QSVVQCHTTN TRMTDSEIFE KRYPVLLHEY SVRLGSGGNG LHKGGDGVVR DIEFLYPLEV
SCLMERRSLA PYGLHGGEEG ARGVNKWIYK SPSGGYKSKS LGGKCTVQVS KGDRVIINTP
GGGGYGCAES NGQSSSGNKE VSNGVQYPIK RATPSRLTGS VGMRDHIQTT N
//