ID G8BE88_CANPC Unreviewed; 1006 AA.
AC G8BE88;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JUN-2023, entry version 47.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN OrderedLocusNames=CPAR2_212290 {ECO:0000313|CGD:CAL0000153847,
GN ECO:0000313|EMBL:CCE43585.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE43585.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
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DR EMBL; HE605206; CCE43585.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BE88; -.
DR STRING; 578454.G8BE88; -.
DR EnsemblFungi; CPAR2_212290-T; CPAR2_212290-T-p1; CPAR2_212290.
DR CGD; CAL0000153847; CPAR2_212290.
DR VEuPathDB; FungiDB:CPAR2_212290; -.
DR eggNOG; KOG1991; Eukaryota.
DR Proteomes; UP000005221; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0051170; P:import into nucleus; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF28; IMPORTIN BETA SMX1; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 24..102
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1006 AA; 114644 MW; 42F3321072391D5F CRC64;
MDKDSLLQAL GGTLDADQHV RKSSEQSLHV YEQQPGFTSY LLDLIIEPGV QLGTQIAAAI
FFKNRVLNYW IAPESTKQPA SYFLLENEKS DIKSKLVPTL MKAHKINQIK FSLSTALNGI
LSYDKWDELT ALIVNLLSSQ DQDQILVGLI CLHEYVKSYR WAGLESKNFS NPVVETIAQE
IFPIIEQLAQ TLISNDGSTV TDEMLYLIVK SFKNATYSSL PAYLMDINKL GLWCKIHISI
INKPLPKELM EEDIPEQRAL HPRVKAVKWC FANMNRLLNK HGGGYLTKEK NDFTQIFLTN
FVPEILSSYW KIIEDWSSRK IWLSEASLFY MISFLELIIE TPCWELVGDK LDAIIGHLIL
PSLQATQETM ELYEDDTFEY IRRFFDVNRE QKTSDVAAIN FVFRLSNKKF KSTINVVFGI
INDIFTQRTN DRGNQEVAMK TEGALRILST ISYKLDQKSS PCHGQVDNML ATYVLPELSN
ENATKTPWLT ARACDTIAMF HNHKYSDMQV LQSIFQGIIT CFQNENQFPI QLTAADALAT
LVQEDSVAAH VADQAPQLLE NLLEKSKKYE SEILTNVMDT FVEKFAKSLE PYAVELGTKL
VEQFLQLCND ILESQSAGGA IETDKEYQAS GLLSTLTTLI LSTSHASKIG TRLETVVQEL
ISFVLENAMV VFLTEIVEIM ESLLYLNQEV TTTMWSMYQS VIDAFETYAY EYFDSFQPFF
VGIVNKGFTN PQVTMQHPYV QSMMNVCFGV LKQEDMDPIF AHSAFEDIEL TILAMDTRIA
SLLPNFLTEI FEIYHNLDAQ NAFDGFMLHR LSLLRILFAA IFVDPVNTVN FIGSRGFTVE
FYKLWIKHSD DFQSVYGCKL QILCALAILK SEAVKSIQED LVGETVDLLI NNVAALPNAI
RTKNSILTNE ISQKDQVKTE VTDDDDNDEF ADIGDLDDEY EMDEAEMEAL RETPIDRVNG
FEEFVQVFLS MQQNEPEKYH ILFGDLDDSK KEMIQELVRV TQQTRR
//
