ID G8BHT5_CANPC Unreviewed; 521 AA.
AC G8BHT5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Poly A polymerase head domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CPAR2_400010 {ECO:0000313|CGD:CAL0000148597,
GN ECO:0000313|EMBL:CCE44199.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE44199.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|ARBA:ARBA00007265,
CC ECO:0000256|RuleBase:RU003953}.
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DR EMBL; HE605208; CCE44199.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BHT5; -.
DR STRING; 578454.G8BHT5; -.
DR EnsemblFungi; CPAR2_400010-T; CPAR2_400010-T-p1; CPAR2_400010.
DR CGD; CAL0000148597; CPAR2_400010.
DR VEuPathDB; FungiDB:CPAR2_400010; -.
DR eggNOG; KOG2159; Eukaryota.
DR Proteomes; UP000005221; Chromosome 4.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:EnsemblFungi.
DR GO; GO:0052929; F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0004810; F:CCA tRNA nucleotidyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0052927; F:CTP:tRNA cytidylyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001680; P:tRNA 3'-terminal CCA addition; IEA:EnsemblFungi.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR PANTHER; PTHR13734:SF5; CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13734; TRNA-NUCLEOTIDYLTRANSFERASE; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW RNA-binding {ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953}.
FT DOMAIN 40..180
FT /note="Poly A polymerase head"
FT /evidence="ECO:0000259|Pfam:PF01743"
FT DOMAIN 207..266
FT /note="tRNA nucleotidyltransferase/poly(A) polymerase RNA
FT and SrmB- binding"
FT /evidence="ECO:0000259|Pfam:PF12627"
SQ SEQUENCE 521 AA; 60395 MW; 405029AE490B115F CRC64;
MRRGIPNVIS LSETESKIRN LLVDYCNHYN ASHQDKPLTL RITGGWVRDK LLGYDSHDID
IAVNHLSGEE FVHNFQKYLK TKDPQFSVNH VHTIKMNPEK SKHLETCTTK LYGIDLDFIN
LRSEEYAHDS RVPTIEFGTP LQDALRRDAT LNALFYNLNE EKIEDFTERG MNDLDNGILR
TPLPPIKTFL DDPLRILRLI RFASKFNFAI EPETLDAMRE KHNQQALSTK ISKERIEIEL
RKILTSHNPS YGLQLINYCD LSKSIFFVEE LKKEFDVYQL ELALSKIPHQ INVASTIYLT
FEQLILNSKI KSVFKKFVVD SDMRFNFWLS VILHPYSIVT TKSKDIYNQY LRLGLMAKKS
DITKISAIAM TSNKTLKRYF SNPDSVKRSD LGIYLRRFPE YIDLNLIVQC YLECVDAIRV
ETPVEIPVPN HSVQCTSDQV KTIQGVIHKY ESLYSTIDSS DLSQVHLMKP LLDGNQLVKY
LQRKPGPWMK PAMDNVLVWQ LDHPQGTKEE CIEFIKSNTV E
//
