ID G8BHV7_CANPC Unreviewed; 470 AA.
AC G8BHV7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCE44221.1};
GN OrderedLocusNames=CPAR2_400220 {ECO:0000313|CGD:CAL0000146639,
GN ECO:0000313|EMBL:CCE44221.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE44221.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
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DR EMBL; HE605208; CCE44221.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BHV7; -.
DR STRING; 578454.G8BHV7; -.
DR EnsemblFungi; CPAR2_400220-T; CPAR2_400220-T-p1; CPAR2_400220.
DR CGD; CAL0000146639; CPAR2_400220.
DR VEuPathDB; FungiDB:CPAR2_400220; -.
DR eggNOG; KOG2751; Eukaryota.
DR Proteomes; UP000005221; Chromosome 4.
DR GO; GO:0006914; P:autophagy; IEA:InterPro.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR041691; Atg6/beclin_CC.
DR InterPro; IPR040455; Atg6_BARA.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR Pfam; PF04111; APG6; 1.
DR Pfam; PF17675; APG6_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221}.
FT DOMAIN 147..288
FT /note="Atg6/beclin coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF17675"
FT DOMAIN 292..466
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
FT COILED 225..263
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 470 AA; 54674 MW; 8488FC379018913F CRC64;
MGNDQYICGD CETPVKLDDS LKRLNRSQLN SLINAKQNKN DQLNDLNPED YISAEKMELY
NRLPKQDKPI HYKSYLDSED EDSEDETNFH LSDSSDINSY LVIEEEEVEQ HNDHADEEEF
ELRLSSRIKV LGNIFNILSN TQDIEHPLSE DCANLLLENY QLKFDQSQKE KDQYLSFLKK
LKMQDQKLNL YENGELKGHL EDDIEPSLNE FRSLIKLEHE RLSELKSLEA TRSDLETQLR
KNKEELSSIN NNQINDILKL RNELQLDLGD RQTKLDQLKA SYNIHLNHID NLRNSNIYKL
MFDIKIDDKY GKINGFRIGY KIVLPEVNAA LGQIVLLLTL ITKRLDLRLK NYKLVPMGSQ
SHIVKFTDSE DGTRHKKILN LYSSDEFTLG RLFNFNKMDV AMIALLEVVA LIEMQLKRID
SELELPYKIY KDTIGGKSIR VTANSEWTQS CKNLLTCLNW VLTFISANTN
//
