ID G8BL83_CANPC Unreviewed; 985 AA.
AC G8BL83;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=S1 motif domain-containing protein {ECO:0000259|PROSITE:PS50126};
GN OrderedLocusNames=CPAR2_700760 {ECO:0000313|CGD:CAL0000151967,
GN ECO:0000313|EMBL:CCE45072.1};
OS Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia
OS parapsilosis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=578454 {ECO:0000313|EMBL:CCE45072.1, ECO:0000313|Proteomes:UP000005221};
RN [1] {ECO:0000313|Proteomes:UP000005221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
RN [2] {ECO:0000313|Proteomes:UP000005221}
RP GENOME REANNOTATION.
RC STRAIN=CDC 317 / ATCC MYA-4646 {ECO:0000313|Proteomes:UP000005221};
RX PubMed=22192698; DOI=10.1186/1471-2164-12-628;
RA Guida A., Lindstaedt C., Maguire S.L., Ding C., Higgins D.G., Corton N.J.,
RA Berriman M., Butler G.;
RT "Using RNA-seq to determine the transcriptional landscape and the hypoxic
RT response of the pathogenic yeast Candida parapsilosis.";
RL BMC Genomics 12:628-628(2011).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR EMBL; HE605209; CCE45072.1; -; Genomic_DNA.
DR AlphaFoldDB; G8BL83; -.
DR STRING; 578454.G8BL83; -.
DR EnsemblFungi; CPAR2_700760-T; CPAR2_700760-T-p1; CPAR2_700760.
DR CGD; CAL0000151967; CPAR2_700760.
DR VEuPathDB; FungiDB:CPAR2_700760; -.
DR eggNOG; KOG2102; Eukaryota.
DR Proteomes; UP000005221; Chromosome 7.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:EnsemblFungi.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0000049; F:tRNA binding; IEA:EnsemblFungi.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0006397; P:mRNA processing; IEA:EnsemblFungi.
DR GO; GO:0070651; P:nonfunctional rRNA decay; IEA:EnsemblFungi.
DR GO; GO:0071028; P:nuclear mRNA surveillance; IEA:EnsemblFungi.
DR GO; GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IEA:EnsemblFungi.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IEA:EnsemblFungi.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:EnsemblFungi.
DR GO; GO:0043628; P:regulatory ncRNA 3'-end processing; IEA:EnsemblFungi.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000005221};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 890..985
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 985 AA; 111165 MW; 1F2CDE9FAF46FC9F CRC64;
MTVQANRKRL STGLTVTSKV FVRSRNGGAL KIVREHYLRN DIPCYSSACT HCQEIVKPDA
NGNLPRFILS ANPAKTTDGK PHYVILDTNI VLHAIDILES TQCFYDVIVP QTVLEEVKNR
SFPIYQRLRN LVKSEDKRFV VFHNEYNEGT YVTREKNESI NDRNDRAIRE VVSWYQKHLP
AIEMILVCND ADSKAKAAKE NLNVKTLVEY LDCLPNGEDL KELIPADFSS FEGKKGEDEV
TFPEYYSNAR IMAGIKNGTL YQGVLNISSY NYLQGEVNVS AFKKPLLIQG SRNLNRAFNS
DSVIVELLPK DKWKEPSTTI IEEETIGVND NPDDGGEDNG NVAASEGVVS DKERLLLAQE
AMKTTKGSTE EKRLQPTAKV VGIARRSWRY YVGQIAPTSV SQEDSGNSAK NCFVILMDKT
LPKIRIRTRK AKEYLGQRIV VVVDSWPSDS KYPNGHFVRA LGEVESAEAE TEALLLEHDV
EYRPFSKNVL DCLPKEGDNW VVPDIANTDD TQLQKRVDLR DKLVCSIDPP NCVDIDDALH
AQKLPNGNYE VGVHIADVTH FVKAGTALDQ EGASRGTSVY LVDKRIDMLP MLLGTNLCSL
KPFVDRFAFS VIWEVDEDAN IVNVKFMKSI IKSRQAFSYE QAQLRIDDPN QNDDLTNSMR
ILLKLSKKLK QKRLDAGALN LASPEVKVHM DSETSDPQEV EIKKLLETNS LVEEFMLFAN
ISVARKIYDA YPQTAMLRRH AAPPATNFET LNDMLNVRKN GLSISTESSK ALADSLDRCV
DHNDPYFNTL IRIMSTRCMM AAEYFPSGSY GYPEFRHYGL AVDIYTHFTS PIRRYCDVVA
HRQLAGAIGY ENLDLSHRDK NKMEMIVRNI NKRHRNAQFA GRASIEYYVG QVMRSNEAEH
EGYVIKSFNN GIVVLVPKFG VEGLIKLETM GDVNSANYDE DKYELTFTDL NGNKRTVGVF
DKVKVDVKSV KDEVSGKRKV QLMLK
//
