ID G8BN48_TETPH Unreviewed; 2450 AA.
AC G8BN48;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Serine/threonine-protein kinase MEC1 {ECO:0000256|ARBA:ARBA00021345};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE AltName: Full=ATR homolog {ECO:0000256|ARBA:ARBA00033001};
DE AltName: Full=DNA-damage checkpoint kinase MEC1 {ECO:0000256|ARBA:ARBA00030459};
DE AltName: Full=Mitosis entry checkpoint protein 1 {ECO:0000256|ARBA:ARBA00029679};
GN Name=TPHA0A02430 {ECO:0000313|EMBL:CCE61326.1};
GN OrderedLocusNames=TPHA_0A02430 {ECO:0000313|EMBL:CCE61326.1};
OS Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE61326.1, ECO:0000313|Proteomes:UP000005666};
RN [1] {ECO:0000313|EMBL:CCE61326.1, ECO:0000313|Proteomes:UP000005666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC {ECO:0000313|Proteomes:UP000005666};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; HE612856; CCE61326.1; -; Genomic_DNA.
DR RefSeq; XP_003683760.1; XM_003683712.1.
DR STRING; 1071381.G8BN48; -.
DR GeneID; 11532380; -.
DR KEGG; tpf:TPHA_0A02430; -.
DR eggNOG; KOG0890; Eukaryota.
DR HOGENOM; CLU_000178_4_0_1; -.
DR OMA; IEYCKKW; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000005666; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF124; SERINE_THREONINE-PROTEIN KINASE MEC1; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005666};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1481..2027
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2131..2434
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2418..2450
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2450 AA; 284417 MW; B41A692742B977B9 CRC64;
METHIKYLDE LIHAIKESRL DTTDDNDFRN NSHLNKCQKF NIPEDNLREQ KSLKIMVTLI
SNLKENTISS YNNNNNNNNN NNNNNKNSLF VENSDLIFNK SIKAIDLLIK SKPYLLWTSF
SIANSQYSKL ESNDYGIISL FEQFTQIAIL NINLSNNNKE DNKMCKSRLW LLRKKLTEWC
GLTSCLHSTT LKVSLSTFIL NRLNSIEKQL TEIVMTTNIN TDELYKMLKE LYVLLYFLSG
QNDKFSNSLT FFDSVSVVNN WDFYFQRSIR IVLFIFGSIR LDLDRPLYLA VLRLELLYFS
LITDYALSGT IKCGSQLKIG STSKLIFVLT TMYQFMKMLQ GMVIEEDDTI AKGLLRVYLI
CISGINANDK NLQQEYSAKF SNQFVNIFKE YLPLDKWLNL NKLDENSMKE VQFNSLSQKS
MLIILFDIKR RCSKENELEF DENNRIWTIK NDLVDKYILH HVISPFSNDQ IQLENLRKRL
IKSFDERVNK KVTELKLLLN KVCPGLLGKY ETDITDLLEE ILARVKISVT TNQQHELVMW
AKVLGLLTCY QVSREKDKSL DIHNWEQCDI CDDNTAHNNF KTIRPDRADA FKFSETYKIM
LKYYLSNVNS INFSVATKAS ILVCMRRIFM HYQPPKLKME SNEIVAEGPC NIFEIISKTF
TGEDRYLRIL SGKLIPLLNI SASHNSEDQH TALLVQFLQS QKNAYLTEVL ISTWIELTLT
TSDEIFDTLL LKLIDIFNSA DYTIHNMMKF QIKSMAKTLN KTPYQLLSPI LPILLRQIGK
NLVERKLTFQ RLIELLGYSP KTILEIYQRY IVPYALTQYK SDAFTEIAKL MSDNDPERMN
IVKANLLEKN SRQIFAVALV KYGLFSLETL EALFLNRLPT FDKGYISAYL PDYRTLAEFL
KLYKNNEFDE VTGNENEKTI ICALRYLVTD FEKDKRHGSK YKNIKDWDTQ REEKFQKKLQ
DNILGIFQVF SCDIHDVEGR TSHYEKVHVV NGISFLIKHA NKKSIISALA QISICLQTAI
EIDEVRFSAL RCWKLLVVSL SDEELSTVID SLISYILENW STFNYKIRST IYEILDILIK
DKSNLVMNIK PFIMIALVNK TELGILVRNN TFARMVSKIR SITDWIPIFA DNLKSNNKYV
IHQTLNNIEL FLKRKQTERS YTFFTNVKQQ SNVTLLLAGL IDASYKFRSI DKSLSEQCTR
CIGLIGTLDM NIYDMRKSMS SENKVYDLND EVQTIKFLVW MLDNILVPAF WQSENPSKQL
FVALVMQESL KFCGLSSASW DINKPELYPN EIKLWSKFNT ISKTTLYPLL SSLYLAQSWK
EYVPLKYPSY NVKEGFKIWI KSLTLDLLKI GTGEDHPLHV FSSLIREDDG TLSNFLLPYI
TMDIIMKADP TSIYEEIMHN LIIEFQFIFN YDLVGLNHHQ IESLKMCFES IFNVIEYCKK
WMTQFKQNYN DSYGTFIIKE ERFLRMLNRT ENFLEAISAN LLAKRSLETN SFERSALYLE
QCMRDSKKST TVTDPNLLLS LQTTYEEIGD IDSIDGLLKT FSTDNLSSKI QELQYSDSWK
MAQYCFESLG NHTEEKHATS KMLKLDFDHQ NYSKVLMNIS PKLPATSMTI DKEMVEWYKM
GIESANLVGD ITILKSWLGN IETLISVSDP ELLLGYNVGK ALSYVNTNQP EKIKNYINKC
FKLIGMHFTA PCREISFIKM QDLLMKLHGL YDINILSNSR DRFLFDCNTS LLDFRMKRVG
ADFVPNHYLL SIRKSFDSLR DVEYTSNDLA KSYFKISQLS RKNSRLDLSC KSLMSCLKFG
QHGEELEFAE ILWTKGENDR AIKLLKEIHE RYQNDLTIEP RDKAIILLKY TEWLDQSNYS
SSEQIIKQYG DVLDLDPQWE KPYYSMGLYY SRLLERKKAE GYETNGRLEY KSISYFLLAF
EKNSIKVRET LPKVVTFWLD TATGAMNEPE GHRKEVLVKT TEDICRSIEN SLQSCPKYIW
YSVLTQLLSR LLHSHSLSSQ LIMNILLNLA LEYPSHMMWY VSVLLNSTSK ERVKRGKYII
EKYGTHCKNV QHIIQSADLV SAFTTVCLKE LKNTSTRSGR SLEKDFNFNM NMAPSSMVVP
VRINLEMLSP LISESMKTYQ PFGSLVTIAR FGSSYKVFSS LKKPKKLNII GSDGKIYGIM
CKKEDVRQDN QYMQFATTMD FMLGKEIGAT KRNLGITTYS VLSLREDCGL IEIVPKVVTL
RSVFVTKYES MKLKYSLKGL YDQWQNVPPD QKLGFHKTQL EKFPPVLHQW FLETFPDPIS
WYNSRNEYSR SYAVMSMVGY ILGLGDRHCE NILLDVETGK VLHVDFDCLF EKGRRLPVPE
IVPFRLTQNL YDALGIMGTE GTFKKSSEIT VSIMRQNEVS LVNVIETIMY DRNMDYSIQK
ALKVLRNKIR GIDSRDGLVL SVPGQVETLI QEAASIENLS QMYIGWLPFW
//
