ID G8BUE1_TETPH Unreviewed; 673 AA.
AC G8BUE1;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN Name=TPHA0F02460 {ECO:0000313|EMBL:CCE63727.1};
GN OrderedLocusNames=TPHA_0F02460 {ECO:0000313|EMBL:CCE63727.1};
OS Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE63727.1, ECO:0000313|Proteomes:UP000005666};
RN [1] {ECO:0000313|EMBL:CCE63727.1, ECO:0000313|Proteomes:UP000005666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC {ECO:0000313|Proteomes:UP000005666};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; HE612861; CCE63727.1; -; Genomic_DNA.
DR RefSeq; XP_003686161.1; XM_003686113.1.
DR AlphaFoldDB; G8BUE1; -.
DR STRING; 1071381.G8BUE1; -.
DR GeneID; 11535656; -.
DR KEGG; tpf:TPHA_0F02460; -.
DR eggNOG; KOG1325; Eukaryota.
DR HOGENOM; CLU_014602_0_0_1; -.
DR OMA; PENETCV; -.
DR OrthoDB; 1826981at2759; -.
DR Proteomes; UP000005666; Chromosome 6.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000005666};
KW Signal {ECO:0000256|RuleBase:RU362103}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT CHAIN 22..673
FT /note="Lysophospholipase"
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT /id="PRO_5005132969"
FT DOMAIN 34..586
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
FT REGION 617..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 71615 MW; ED0A42A7A5A6A29F CRC64;
MQLFSFLVTA PLLASILEVQ AWSPHNSYTP ANVTCPNDFN LIREGASSLS SNETEWLSRR
DEITKAALKE FLQRATSNFT DSSIVNEIFG ASNSSNSSNS TVSKLRVGIA ASGGGYRAML
SGAGMVAAFD NRTIGANAYG FGGLLQGSTY LSGLSGGNWL TGTLAWNNWT SVQDIIDNTY
TDNSIWDITD GLVSGTANNT LMWETIFAEV AGKSAAGYNT SLADYWGRGL AYNFFPNLPN
GGSGYTWSTL RDSNVFLNAE MPFPITVTDA RDPNTTISYV NSTIVEFNPF EMGSWDPSLN
SFADVKYIGS AVNNGSPIVD GVCAAGFDNA GFIIGTSSTL FTPAMSSAVG TLLGNSSSTV
GTFLVNEIAV DTNDVANFGP NPFYGSSFGI SNIGNKDILT LADGGEDNIE LPLIALIQKQ
RDLDVVFALD NSADTAENWP DGNGLISAYR RQFYPQGSNI SFPYVPDAET FVSEGLNKRP
TFFGCDAANL TNLAYVPPLI VYLPNYEVSY ASNTSTLQLA YNETERLSMI QNGFEAVTRG
NFTEDSKFLG CVACAVMRRS QESLGLDLPS ECQSCFDTYC WDGSLSDSAA LDSAANSTST
ISSTSASNST TMSISMTTST SASSSNNNGT SASSNSTPSR SSTSSHNGAT SLDVTTKITL
VTVFIFNFLL GNF
//
