ID G8BX44_TETPH Unreviewed; 703 AA.
AC G8BX44;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN Name=TPHA0H01420 {ECO:0000313|EMBL:CCE64348.1};
GN OrderedLocusNames=TPHA_0H01420 {ECO:0000313|EMBL:CCE64348.1};
OS Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE64348.1, ECO:0000313|Proteomes:UP000005666};
RN [1] {ECO:0000313|EMBL:CCE64348.1, ECO:0000313|Proteomes:UP000005666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC {ECO:0000313|Proteomes:UP000005666};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR EMBL; HE612863; CCE64348.1; -; Genomic_DNA.
DR RefSeq; XP_003686782.1; XM_003686734.1.
DR AlphaFoldDB; G8BX44; -.
DR STRING; 1071381.G8BX44; -.
DR GeneID; 11534033; -.
DR KEGG; tpf:TPHA_0H01420; -.
DR eggNOG; KOG0995; Eukaryota.
DR HOGENOM; CLU_012583_1_2_1; -.
DR OMA; PSHKFQK; -.
DR OrthoDB; 5490442at2759; -.
DR Proteomes; UP000005666; Chromosome 8.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW Reference proteome {ECO:0000313|Proteomes:UP000005666}.
FT DOMAIN 291..357
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 48..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 385..457
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 548..582
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 606..703
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 95..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 703 AA; 82008 MW; 268B7EE9008CDD08 CRC64;
MQNIQQPILN NLNPQLFTSQ IPAPSTGIKR RQSVSNVALT DMINSSIAKN AHSNKSDPNN
RKKLRSTVSS VNQLYNQKRT SYIRDNEPSG MQRHSMLPYP TNNNNDNNNN DLNTNNVSTR
DPRPLRDKNF QNAMQQDIIN YLTSNKFEIE TNLPITNKTL KQPTQKGFII TFQWLYQRLD
PGYQFKSNNS NNVNSNTNKS VELEIYQILK FLQYPYLDTI NKSQISAVGG NSWHKFLGML
HWMVKTNISL DKSLKILDKS LIDENTQDLK SINEQNKLPL TQEEQDSKQD KYEVLIEQIC
INYIIECYKK YLKNDDNFEP ILKDLNEEFK KFNHIFDIDL NSLRSKTEAL SVECDGLVKI
YENLKLSRDK NIALKSDLSK FQNYVDGMKN KSNEWSQKLE KMNNEKALRE DDIRDISEEI
SSIKKFLKDK NISIDVISNK NLEFEKLSKD LDQKKDEVNK FVSSTQSLKI EFESIMKALN
DTLRQYDLST ETLINERISL GHSTIKKSDF ELLIDDSIKQ NYNSYLNNGK AIDFNKMFKN
DLNTMKIKNN IIKLNNEIQE RIEGVEKNNS VLEQKLISLK QEVMDKNKMT ENVELKLSEA
NSTYELNKQE SDNKLLKQKI EIEKLERKIN DANKILKEKL LETQQLINST RLKKEELQLQ
LDREKNNISK KILEIIDFSG NIMERIQNKL ESSQSIINKE LEN
//
