ID G8BZV5_TETPH Unreviewed; 660 AA.
AC G8BZV5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Golgi apyrase {ECO:0008006|Google:ProtNLM};
GN Name=TPHA0L00770 {ECO:0000313|EMBL:CCE65433.1};
GN OrderedLocusNames=TPHA_0L00770 {ECO:0000313|EMBL:CCE65433.1};
OS Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE65433.1, ECO:0000313|Proteomes:UP000005666};
RN [1] {ECO:0000313|EMBL:CCE65433.1, ECO:0000313|Proteomes:UP000005666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC {ECO:0000313|Proteomes:UP000005666};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR EMBL; HE612867; CCE65433.1; -; Genomic_DNA.
DR RefSeq; XP_003687867.1; XM_003687819.1.
DR AlphaFoldDB; G8BZV5; -.
DR STRING; 1071381.G8BZV5; -.
DR GeneID; 11531701; -.
DR KEGG; tpf:TPHA_0L00770; -.
DR eggNOG; KOG1386; Eukaryota.
DR HOGENOM; CLU_010246_3_3_1; -.
DR OMA; WHDALFD; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000005666; Chromosome 12.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProt.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF121; NUCLEOSIDE-DIPHOSPHATASE MIG-23; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005666};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 494..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 146
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 181..185
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 660 AA; 74437 MW; CBE40D3DB9B7EE71 CRC64;
MLTDGLLNEN YGIVIDAGSS GSRIHVYKWN NSKPDSEDAR NSVPQIHQEA DWTSKTTPGL
SSYEKKPHKA FKKHIKPLLD YAEKIVPKNK IKETPVFIQA TAGMRLLPEK RQQQILSDLC
DGFKHSSNFL MKNCEAQIQI IDGETEGLYG WLSLNYLKGM FNNYDAKSDT HFTFGFMDMG
GASTQIAFSP SDKEQVKKHK EDIPTIYLRT LNGEIQKWDV FVSSWLGFGA NQARKRYFAQ
LVNSLPENVN DYDDDNYATR KISDPCMPKG CESKFELYDK KFTAVGTGHS EQCEKLIYPL
LLKQLPCIDE PCLFNGVHAP QIDFLNDKFV GVSEYWYTAN DVFKLGGEYN FQDFSSGVKE
FCNSNWSDIK KKGDEGYYNS IPDSYLAASC FKANWVLNVL HEGFGLPFEK PADASQSMVD
HPTFQSAEKI DSHEISWTLG RILLYASGSI LAGSKDAIVG IQPSKLSAQH FGKKFIPGSL
EDFSNQIESS IGAIFNKLVV VLLVIFIVCF MLLKLKIINK SDLPPFINSI HETVQMKINS
YYHYNRMVDS LSNLEEGISM EASNYVTKPT RDIDLKLRSK SMQGLDEISA KHGMDFGLKV
RSKTHVGAPF NKSRNDTSPT SQGKLKTAFS LADFSKYKLE KITIRICHFC LLKSSLSNIM
//
