ID   G8C080_TETPH            Unreviewed;      1276 AA.
AC   G8C080;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=IPT/TIG domain-containing protein {ECO:0000259|SMART:SM00429};
GN   Name=TPHA0L02060 {ECO:0000313|EMBL:CCE65558.1};
GN   OrderedLocusNames=TPHA_0L02060 {ECO:0000313|EMBL:CCE65558.1};
OS   Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS   Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX   NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE65558.1, ECO:0000313|Proteomes:UP000005666};
RN   [1] {ECO:0000313|EMBL:CCE65558.1, ECO:0000313|Proteomes:UP000005666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC   {ECO:0000313|Proteomes:UP000005666};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR   EMBL; HE612867; CCE65558.1; -; Genomic_DNA.
DR   RefSeq; XP_003687992.1; XM_003687944.1.
DR   AlphaFoldDB; G8C080; -.
DR   STRING; 1071381.G8C080; -.
DR   GeneID; 11531817; -.
DR   KEGG; tpf:TPHA_0L02060; -.
DR   eggNOG; KOG3836; Eukaryota.
DR   HOGENOM; CLU_004311_0_0_1; -.
DR   OMA; CIARQKF; -.
DR   OrthoDB; 2901153at2759; -.
DR   Proteomes; UP000005666; Chromosome 12.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00102; IPT; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005666};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1201..1220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          685..776
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   REPEAT          870..902
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          903..935
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          394..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..831
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1071..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1071..1089
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1276 AA;  143407 MW;  26B1D3DBB5FF8969 CRC64;
     MAEVNRESGN PIVRKNEIFD VLDEFLYPNS SPSNSKGNKF NNNNNIMKSN VNDFDEEIFN
     AFIKTDSLDF RQHDDHNDYR DVTKVKAEAD AGTGVTLDQY NDTKVYEHGY SLNAENHSFM
     ATNGDEKQDD DGITTTTTMD NDGTHKKTKS SITNTQNIYE ILIENTVSFG ERDVSVSSNL
     DSHDTLASLK NAEEKLNKIN ELVNMDENLL PNKLIISKLP HQCRVENQIN ISIQIEPPLT
     KQHILHLSSN NVAKNKLFLS KDIDNYPKNF LDEIVFLESF LLCSETNKIA NVCPMCINRE
     QRRASRRKSG LCDNILWCQN ENRSALIFNS KQILPISSVA KHLQAFKLTA RMVCYSRHHK
     SSKGFKILFI LKNLHGDLLA KSISDSILIM DKKPSSSMNG ESNKNKSATS SNFKTNASLS
     PSNDKKNKHS KTYSNSNTDL SMDIDSNMDT DAYYSTNLSE ASTNYASMSD AQYNTNQIVQ
     PYTHNTSLPN VNDPNAMMLP SQNNEYDSNN HNGNSMFNFT SPQTHIPSHN RVPSQSQLPP
     QLNSQQQLLM LNSFMQQSGM PIIPSPTSMS EDGLDQNKSR SIKTASSTQI AARRNEYING
     SARPKRQRSD IADTKYHSDN MNHSPLSWIN NSNNSNNNQF NQTLQNNANQ PVNAAAFTNR
     TTDNNMPMVN TVSQNSNDNN IKMNLPLIQR AIPSQGPITG GIEITLLGSN FRNGLTIKFG
     DNVTLSTQCW SDSTMVTYLP PAATAGQVFI IAEDPKYPNQ FVNQSNSNKN AVFTYLDDTD
     RQLIELALQI VGLKMNGKLE DARNIAKRIV GNDENSPNIS PANGSAASTG NSNYSKYSSQ
     LEGSYSDEQL IVKVINSLNA TSNLSMCDSN GRTLLHLAAL KGYEQLVMTL IKYGARIDEK
     DMFGYTPLHF ACVNGEYKII AFLLKCKADL TIKAKNGVHA RDVYMVNHGN DEISSDDYNR
     VIKMFDSLEK GSKLEFNNSS SGDFDLDSLH SLEYDIEPSI TVNSRGKTHK GPTTVAVSVS
     EDSGYEVSDG ESFITNDSDL SSMNSESRDF INTENNGNNV FNIERSTSKK LREANELEEN
     TEITNDESKG TETENNSVNY ADRNNDSLWN RMLNRINDDL PKYEDLFPGF THPSKAKQQT
     TSMMDEEQAV TMNKTKDMSV LSSNTDDLSQ TSSEDEDDAI QIRLNRFFQQ QRETTFQNDK
     MLWFFWFPLS IILISTYFFI KFGSIDDSKL YSFSFEIVDR FRKSLAKLML GNDRMKAAFK
     EQLSNFQNTG IHVPVM
//