ID G8C0U7_TETPH Unreviewed; 981 AA.
AC G8C0U7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=ATP-dependent RNA helicase DBP10 {ECO:0000256|ARBA:ARBA00019117};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=ATP-dependent RNA helicase dbp10 {ECO:0000256|ARBA:ARBA00021760};
GN Name=TPHA0M00330 {ECO:0000313|EMBL:CCE65608.1};
GN OrderedLocusNames=TPHA_0M00330 {ECO:0000313|EMBL:CCE65608.1};
OS Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL
OS Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071381 {ECO:0000313|EMBL:CCE65608.1, ECO:0000313|Proteomes:UP000005666};
RN [1] {ECO:0000313|EMBL:CCE65608.1, ECO:0000313|Proteomes:UP000005666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5
RC {ECO:0000313|Proteomes:UP000005666};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of 60S
CC ribosomal subunits and is required for the normal formation of 25S and
CC 5.8S rRNAs. {ECO:0000256|ARBA:ARBA00003706}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC subfamily. {ECO:0000256|ARBA:ARBA00010379}.
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DR EMBL; HE612868; CCE65608.1; -; Genomic_DNA.
DR RefSeq; XP_003688042.1; XM_003687994.1.
DR AlphaFoldDB; G8C0U7; -.
DR STRING; 1071381.G8C0U7; -.
DR GeneID; 11531873; -.
DR KEGG; tpf:TPHA_0M00330; -.
DR eggNOG; KOG0337; Eukaryota.
DR HOGENOM; CLU_003041_5_1_1; -.
DR OMA; EDQFGMM; -.
DR OrthoDB; 5475716at2759; -.
DR Proteomes; UP000005666; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0030684; C:preribosome; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProt.
DR CDD; cd17959; DEADc_DDX54; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR012541; DBP10_C.
DR InterPro; IPR033517; DDX54/DBP10_DEAD-box_helicase.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF8; RNA HELICASE; 1.
DR Pfam; PF08147; DBP10CT; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM01123; DBP10CT; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005666};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 124..152
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 155..327
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 401..558
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 124..152
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 39..64
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..971
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 111155 MW; 44311DE2B5621D8F CRC64;
MSRSVNKRSM SADSDDSDFE DNGVDIAKSI AFNASGSDSS DDSDEEDDFK VDDGVQDLIE
YSDEETTEKE VKKTKKASNP FPLLEMSDDE DDKNSKNSAF NDDADDVNDY FSTNMQDKSK
HKKGSFPSFG LSKLILSNIN KKGFRQPTPI QRKTIPLILQ RRDIVGMART GSGKTAAFIL
PMIEKLKTHS GKIGARAVIL SPSRELAMQT HKVFKDFSRG SQLRSVLLTG GDSLEEQFSM
MMSNPDVIVA TPGRFMHLKV EMGLDLKTVE YVVFDEADRL FEMGFQEQLN ELLASLPMNR
QTLLFSATLP NSLVDFAKAG LTNPVLVRLD AESKISENLQ LAFFSTKNEE REATLLYILQ
DVIDLQIGTE EEIKKLTASN KRSDEIDSDN EREQADRKLN KKKKFEKFIK PKLPSANELP
SEKATIVFVP TRHHVEYISN LLKDCGYLVS YLYGTLDQHA RKHQLFNFRA GLTSILVVTD
VAARGVDIPM LANVINYSLP ASSKIFVHRV GRTARAGNKG WAYSIASETE LPYLLDLELF
LGKKILLTQM YEATCSLAKN KWIAAGNEEY TFQPPKPSYT DRMILGSCPR LELENIGDLY
KNIMSASFDL QMAKKTSLKA EKLYFRTRTA ASPESIKRGK ELIASGWDEQ HIMFGKNVEK
EKLDFLSKFQ NRNNKETVFE FGRNPTDATA VLMNRRRRQL APIQRKAVER RKLLEKERLA
GLSHALEDEI LKGEDHESGY TISKEALAAF EDADKLLQEQ EKKKRKPKTY KDPQFFLSHY
APAKDIQDKQ LNLTSGFTND AAQAAYDLNN DDKVQVHKQT ANIKWDKGRK KYVNINGLDN
KKYIIGEGGQ KIPASFKSGR FDEWSKARHI KPLKAGVRED SIPTNLLADV TGPSDGSRTF
GGRFKHKQNK APRLPDKHRD DYESQKKKVQ NALERGVQVK GYNNRNSVKS ELKTVAQIRK
ERMVNENKQK KNARPSKKRK Y
//
