ID G8DGJ4_9PHYC Unreviewed; 1123 AA.
AC G8DGJ4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=EMVG_00132 {ECO:0000313|EMBL:AET73418.1};
OS Emiliania huxleyi virus PS401.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Algavirales; Phycodnaviridae.
OX NCBI_TaxID=754068 {ECO:0000313|EMBL:AET73418.1, ECO:0000313|Proteomes:UP000248154};
RN [1] {ECO:0000313|EMBL:AET73418.1, ECO:0000313|Proteomes:UP000248154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Henn M.R., Martinez Martinez J., Wilson W., Gilg I., Wharam S., Levin J.,
RA Malboeuf C., Casali M., Russ C., Lennon N., Chapman S.B., Erlich R.,
RA Young S.K., Yandava C., Zeng Q., Alvarado L., Anderson S., Berlin A.,
RA Chen Z., Freedman E., Gellesch M., Goldberg J., Green L., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D., Hollinger A., Howarth C., Larson L.,
RA Mehta T., Pearson M., Roberts A., Ryan E., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Emiliania huxleyi virus PS401.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; HQ634146; AET73418.1; -; Genomic_DNA.
DR Proteomes; UP000248154; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 2.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 169..464
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 538..774
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 836..1046
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 788..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 124843 MW; F478E505D26D0F33 CRC64;
MTVQLVRGTG VAASLPTDIE SIGLSLRVEI TSAALKGVPL YLLDVAVEDK IYDRVTVGRR
TGPDGADLMP TWLKSKSGWE WAEKVHSFIF AAKADGSTVA LQCDGFQPSL IWRADSRNAA
QTLVKQLASR LGWRRRDDEP PLKLRWDFDR RKQTCGFVPS DENPREAKRF GVVRVYFPSV
RMRRQAMKLT FPGLEMHEDN IAPVQQFIEQ MRVSPCTWFE ISNCTTPSRF INGSLRWSTE
DVEAGCSVQH IRALPPDHPL SATVPDLAIL SYDIEAHSTT FNPDGSHKFP NAEQPGDEVL
SIQYNLSRYT SGVVYRVCVY NLRRPESAAG TPCELPEPLD GCDVFYVDTE KEVLDFHGDL
LASFNPSVVA GHNVLYFDER YLHTRNETLA SLPSRDNDPR PTASQRFRHM SKAIAQRVEK
RETKSESEQR GKRFKCTSDW RGRLFVDTYE YTQLNYRLDS NRLDFIGRKF CGEHKEDLSP
EELFDAADSR DPARIRQILV YGIQDADLVQ KLLVALKAIL ATFVDAQQHN ALVDTLTFRG
PSAKAFAYIC KRAHDNGRFV DRFPEWINAS DDYEGATVFD AKVGLYHAWY NGKFLAVWDF
SSLYPSLMRS YGICPSSYVR PGQRVPSECE VQNFEVAAGR VHRFVRCEQE PVFPDAVGAL
VSGRNEAKKR KREATTEDEC DVWETVQKAR KVCCNSLYGF LGANGHIDPD TKERVGAGPL
PLVAAAETIT FLGRRSIERA AELCKQALAE RGLRSATVYG DTDSCFLWGM YDDVSYVNTE
VLVAAGDSGS SEGDSGSAGS EGDVAGSGGA AAGVRVRFRV SAASIADKCK KIDKMMTEVG
KEVSATLSEG TIVPLELAFE KSSGTTKKGG CALISKKRYA MILREPGEEE GTLKIQGLET
KRRDQPATSR KLMEAVFNPL LRGEHEAAAD LIVGEIGKMV RDEVPLADYV ISKTLSRDPF
ASEADGGYAL PENMEVVHVA RKIVARRGEG AAPQVNDRLP FVHVYMPTAE GVAEKCDCPK
HVEEAGLKVD IPYYITRAGK ACERIFLEKE FPESFARVQR EFLKGAQVST QLLRGTKTVC
SLGASSSDAP VAETGRVRSR DELFDGVEGM RVGIRRGKRV KKW
//
