ID   G8DP07_9REOV            Unreviewed;       529 AA.
AC   G8DP07;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Outer capsid protein VP5 {ECO:0000256|ARBA:ARBA00015353};
OS   Umatilla virus.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Orbivirus.
OX   NCBI_TaxID=40060 {ECO:0000313|EMBL:AEE98373.1, ECO:0000313|Proteomes:UP000204084};
RN   [1] {ECO:0000313|EMBL:AEE98373.1, ECO:0000313|Proteomes:UP000204084}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA1969/01 {ECO:0000313|EMBL:AEE98373.1};
RX   PubMed=21897849; DOI=10.1371/journal.pone.0023605;
RA   Belaganahalli M.N., Maan S., Maan N.S., Tesh R., Attoui H., Mertens P.P.;
RT   "Umatilla virus genome sequencing and phylogenetic analysis: identification
RT   of stretch lagoon orbivirus as a new member of the Umatilla virus
RT   species.";
RL   PLoS ONE 6:E23605-E23605(2011).
CC   -!- FUNCTION: VP5 protein is one of the two proteins (with VP2) which
CC       constitute the virus particle outer capsid. Acts as a membrane
CC       permeabilization protein that mediates release of viral particles from
CC       endosomal compartments into the cytoplasm. Permeabilization activity is
CC       probably negatively regulated by VP2 and is triggered by endosomal
CC       degradation of VP2 and exposure to low pH.
CC       {ECO:0000256|ARBA:ARBA00024835}.
CC   -!- SIMILARITY: Belongs to the orbivirus VP5 family.
CC       {ECO:0000256|ARBA:ARBA00007624}.
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DR   EMBL; HQ842624; AEE98373.1; -; Genomic_RNA.
DR   RefSeq; YP_009047263.1; NC_024508.1.
DR   GeneID; 19893521; -.
DR   KEGG; vg:19893521; -.
DR   OrthoDB; 8954at10239; -.
DR   Proteomes; UP000204084; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR000145; Capsid_VP5_Orbivir.
DR   Pfam; PF00901; Orbi_VP5; 1.
PE   3: Inferred from homology;
SQ   SEQUENCE   529 AA;  58600 MW;  C14761193D83F9D6 CRC64;
     MGKISNAISK FGTGIKRAAK SDITKTILQA AASGVTRFAE SEVGQRTIEG LVQGTAQTVL
     TGGSLGENVK KAVVTNVLGT HDIVTDPLDP VKHQMAAQLD EIKDKVESDK LRAEMATVVK
     SKLAPINTEL TKIENHLKQV HNNGKIEQNE IEILESAIKA LSHVVEIDQK GLKRLRHVLQ
     KEERNRSSEE KAILNAMATN YESLRSMIAR ERDGLIEEAV EQTLDISGEI AEHLAAEVPL
     VGETLATGIA TGRGVVQMYR LGQLIAEMGN LPMDHVVLPA ITQGSLEVML TADDSLEEQH
     LMQILESKIE HVDSIKREVD HLSENVVPII TTAAHQESLR LGGKGTTIPQ TVKAALHIPK
     KSRPAIHFYT APWDSDYVVM FHVIGPYHSG ESFLLCVDLA TDYISRYDIY VPGHHASNPR
     IQKDVMTLQM AMDEFLKEAS QVGGSTYIHQ ERLARGVGQK AIYIGSQPYT SFYSSMYRNA
     EKLVREREVQ MHVFRGPIAL QRRTLLNVLM HGIVIINDNI REGRAFNRD
//