ID G8F456_MACFA Unreviewed; 401 AA.
AC G8F456;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Arylacetamide deacetylase like 2 {ECO:0000313|Ensembl:ENSMFAP00000035256.1};
GN Name=AADACL2 {ECO:0000313|Ensembl:ENSMFAP00000035256.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000035256.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000035256.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000035256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 'GDXG' lipolytic enzyme family.
CC {ECO:0000256|ARBA:ARBA00010515}.
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DR RefSeq; XP_005546184.1; XM_005546127.1.
DR AlphaFoldDB; G8F456; -.
DR SMR; G8F456; -.
DR STRING; 9541.ENSMFAP00000035256; -.
DR MEROPS; S09.068; -.
DR Ensembl; ENSMFAT00000009491.2; ENSMFAP00000035256.1; ENSMFAG00000042922.2.
DR GeneID; 102130423; -.
DR KEGG; mcf:102130423; -.
DR VEuPathDB; HostDB:ENSMFAG00000042922; -.
DR eggNOG; KOG1515; Eukaryota.
DR GeneTree; ENSGT00940000161405; -.
DR OMA; DHVYTEP; -.
DR OrthoDB; 1144477at2759; -.
DR Proteomes; UP000233100; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR017157; Arylacetamide_deacetylase.
DR InterPro; IPR033140; Lipase_GDXG_put_SER_AS.
DR PANTHER; PTHR23024; ARYLACETAMIDE DEACETYLASE; 1.
DR PANTHER; PTHR23024:SF223; ARYLACETAMIDE DEACETYLASE-LIKE 2; 1.
DR Pfam; PF07859; Abhydrolase_3; 2.
DR PIRSF; PIRSF037251; Arylacetamide_deacetylase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01174; LIPASE_GDXG_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..401
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014304294"
FT DOMAIN 107..257
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 311..373
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT ACT_SITE 189
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1,
FT ECO:0000256|PROSITE-ProRule:PRU10038"
FT ACT_SITE 341
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
FT ACT_SITE 371
FT /evidence="ECO:0000256|PIRSR:PIRSR037251-1"
SQ SEQUENCE 401 AA; 46048 MW; 81E01F4092725DF0 CRC64;
MMLKALCLGL LCVIFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF ENMGIMRYEE
FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS ETRRRAVIYF HGGGFCFGSS
KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ HHFPAQFEDG LAAVKFFLLE KILTKYGVDP
TRICISGDSS GGNLATAVTQ QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV
LTRDVAIKLV SLYFTKDEAL PRAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP
ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DVLRDDGLMY VTRLRNVGVQ
VVHDHIEDGI HGALSYMTSP FYLRLGLRIR DMYVSWLDKN L
//
