ID G8F4B7_MACFA Unreviewed; 1222 AA.
AC G8F4B7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Dermatan-sulfate epimerase-like protein {ECO:0000313|EMBL:EHH62131.1};
GN ORFNames=EGM_20339 {ECO:0000313|EMBL:EHH62131.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN [1] {ECO:0000313|EMBL:EHH62131.1, ECO:0000313|Proteomes:UP000009130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH62131.1,
RC ECO:0000313|Proteomes:UP000009130};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dermatan-sulfate isomerase family.
CC {ECO:0000256|ARBA:ARBA00006556}.
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DR EMBL; JH330730; EHH62131.1; -; Genomic_DNA.
DR AlphaFoldDB; G8F4B7; -.
DR eggNOG; ENOG502QPWZ; Eukaryota.
DR Proteomes; UP000009130; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 2.70.98.70; -; 1.
DR Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008929; Chondroitin_lyas.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR15532; -; 1.
DR PANTHER; PTHR15532:SF2; DERMATAN-SULFATE EPIMERASE-LIKE PROTEIN; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 863..1171
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
SQ SEQUENCE 1222 AA; 140166 MW; 02274703AA58A057 CRC64;
MPKGGAPPWI MALMFTGHLL FLVLLMFALS TFEESVSNYS EWAVFADDID QFKTQKVQDF
RPNQKLKKSM LHPSLYFDAG EIQAMRQKSR TSHLHLFRAI RSAVTVMLSN PTYYLPPPKH
ADFAAKWNEI YGNNLPPLAL YCLLCPEDKV AFEFVLEYMD RMVGYKDWLV ENAPGDEVPI
GHSLTGFATA FDFLCNLLDN HRRQKYLEKI WVITEEMYEY SKVRSWGKQL LHNHQATNMI
ALLTGALVTG VDKGSKANIW KQAVVDVMEK TMFLLNHIVD GSLDEGVAYG SYTAKSITQY
VFLAQRHFNI NNLDNNWLKM HFWFYYATLL PGFQRTVGIA DSNYNWFYGP ESQLVFLDKF
ILKNGAGNWL AQQIRKHRPK DGPMVPSTAQ RWSTLHTEYI WYDPQLTPQP PAEYGTAKIH
TFPNWGVVTY GAGLPNTQTN TFVSFKSGKL GGRAVYDIVH FQPYSWIDGW RSFNPGHEHP
DQNSFTFAPN GQVFVSEALY GPKLSHLNNV LVFAPSPSSQ CNKPWEGQLG ECAQWLKWTG
EEVGDAAGEI ITASQHGEMI FVSGEAVSAY SSAMRLKSVY RALLLLNSQT LLVVDHIERQ
EDSPINSVSA FFHNLDIDFK YIPYKFMNRY NGAMMDVWDA HYKMFWFDHH GNSPMASIQE
AEQAAEFKKR WTQFVNVTFQ MESTITRIAY VFYGPYINVS SCRFIESSDS GLQISLNVNN
TEHVVSIVTD YHNLKTRFNY LGFGGFASVA DQGQITRFGV GTQAIVKPVR HDRIIFPFGF
KFNIAVGLIL CISLVILTFQ WRFYLSFRKL MRWILILVIA LWFIELLDVW STCSQPICAK
WTRTEAEGSK KSLSSEGHHV DLPDVVITSL PGSGAEILKQ LFFNSSDFLY IRVPTAYIDI
PETEFEIDSF VDACEWKVSD IRSGHFRLLR GWLQSLVQDT KLHLQNIHLH EPNRGKLAQY
IAVNKDKKRK FKRRESLPEQ RSQMKGAFDR DAEYIRALRR HLVYYPSARP VLSLSSGSWT
LKLHFFQEVL GASMRALYIV RDPRAWIYSM LYNSKPSLYS LKNVPEHLAK LFKIEGGKGK
CNLNSGYAFE YEPLRKELSK SKSNAVSLLS HLWLANTAAA LRINTDLLPT SYQLVKFEDI
VHFPQKTTER IFAFLGIPLS PASLNQILFA TSTNLFYLPY EGEISPTNTN VWKQNLPRDE
IKLIENICWT LMDRLGYPKF MD
//