ID G8F5J6_MACFA Unreviewed; 1262 AA.
AC G8F5J6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Chromodomain-helicase-DNA-binding protein 4 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=EGM_20938 {ECO:0000313|EMBL:EHH62560.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN [1] {ECO:0000313|EMBL:EHH62560.1, ECO:0000313|Proteomes:UP000009130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH62560.1,
RC ECO:0000313|Proteomes:UP000009130};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; JH331776; EHH62560.1; -; Genomic_DNA.
DR AlphaFoldDB; G8F5J6; -.
DR eggNOG; KOG0383; Eukaryota.
DR Proteomes; UP000009130; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18056; DEXHc_CHD4; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR012957; CHD_C2.
DR InterPro; IPR009462; CHD_II_SANT-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR009463; DUF1087.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF22; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 4; 1.
DR Pfam; PF08074; CHDCT2; 1.
DR Pfam; PF06461; CHDII_SANT-like; 1.
DR Pfam; PF06465; DUF1087; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01146; DUF1086; 1.
DR SMART; SM01147; DUF1087; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 64..248
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 380..529
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 655..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..912
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH62560.1"
FT NON_TER 1262
FT /evidence="ECO:0000313|EMBL:EHH62560.1"
SQ SEQUENCE 1262 AA; 143877 MW; F0C69C7206BA16BA CRC64;
RELMRGEEGR PGKKLKKVKL RKLERPPETP TVDPTVKYER QPEYLDATGG TLHPYQMEGL
NWLRFSWAQG TDTILADEMG LGKTVQTAVF LYSLYKEGHS KGPFLVSAPL STIINWEREF
EMWAPDMYVV TYVGDKDSRA IIRENEFSFE DNAIRGGKKA SRMKKEASVK FHVLLTSYEL
ITIDMAILGS IDWACLIVDE AHRLKNNQSK FFRVLNGYSL QHKLLLTGTP LQNNLEELFH
LLNFLTPERF HNLEGFLEEF ADIAKEDQIK KLHDMLGPHM LRRLKADVFK NMPSKTELIV
RVELSPMQKK YYKYILTRNF EALNARGGGN QVSLLNVVMD LKKCCNHPYL FPVAAMEAPK
MPNGMYDGSA LIRASGKLLL LQKMLKNLKE GGHRVLIFSQ MTKMLDLLED FLEHEGYKYE
RIDGGITGNM RQEAIDRFNA PGAQQFCFLL STRAGGLGIN LATADTVIIY DSDWNPHNDI
QAFSRAHRIG QNKKVMIYRF VTRASVEERI TQVAKKKMML THLVVRPGLG SKTGSMSKQE
LDDILKFGTE ELFKDEATDG GGDNKEGEDS SVIHYDDKAI ERLLDRNQDE TEDTELQGMN
EYLSSFKVAQ YVVREEEMGE EEEVEREIIK QEESVDPDYW EKLLRHHYEQ QQEDLARNLG
KGKRIRKQVN YNDGSQEDRG VCGRPRPPPM GRSTRAVGPA HLPSLPPDWQ DDQSDNQSDY
SVASEEGDED FDERSEAPRR PSRKGLRNDK DKPLPPLLAR VGGNIEVLGF NARQRKAFLN
AIMRYGMPPQ DAFTTQWLVR DLRGKSEKEF KAYVSLFMRH LCEPGADGAE TFADGVPREG
LSRQHVLTRI GVMSLIRKKV QEFEHVNGRW SMPELAEVEE NKKMSQPGSP SPKTPTPSTP
GDTQPNTPAP APPAEDGIKI EENSLKEEES IEGEKEVKSV APETAIECTQ PPAPASEDEK
VVAEPPEGEE KVEKAEVKER TEEPMETEPK GAADVEKVEE KSAIDLTPIV VEDKEEKKEE
EEKKEVMLQN GETPKDLNDE KQKKNIKQRF MFNIADGGFT ELHSLWQNEE RAATVTKKTY
EIWHRRHDYW LLAGIINHGY ARWQDIQNDP RYAILNEPFK GEMNRGNFLE IKNKFLARRF
KLLEQALVIE EQLRRAAYLN MSEDPSHPSM ALNTRFAEVE CLAESHQHLS KESMAGNKPA
NAVLHKVLKQ LEELLSDMKA DVTRLPATIA RIPPVAVRLQ MSERNILSRL ANRAPEPTPQ
QV
//
