ID G8JSC7_ERECY Unreviewed; 597 AA.
AC G8JSC7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Ecym_4620 {ECO:0000313|EMBL:AET39649.1};
OS Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 /
OS NRRL Y-17582) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=931890 {ECO:0000313|EMBL:AET39649.1, ECO:0000313|Proteomes:UP000006790};
RN [1] {ECO:0000313|Proteomes:UP000006790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582
RC {ECO:0000313|Proteomes:UP000006790};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
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DR EMBL; CP002500; AET39649.1; -; Genomic_DNA.
DR RefSeq; XP_003646466.1; XM_003646418.1.
DR AlphaFoldDB; G8JSC7; -.
DR STRING; 931890.G8JSC7; -.
DR GeneID; 11470177; -.
DR KEGG; erc:Ecym_4620; -.
DR eggNOG; KOG2327; Eukaryota.
DR HOGENOM; CLU_024202_0_0_1; -.
DR InParanoid; G8JSC7; -.
DR OMA; LPWLDDI; -.
DR OrthoDB; 21093at2759; -.
DR Proteomes; UP000006790; Chromosome 4.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF2; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR PIRSF; PIRSF003033; Ku70; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006790};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 311..454
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT ACT_SITE 17
FT /note="Schiff-base intermediate with DNA; for 5'-
FT deoxyribose-5-phosphate lyase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR003033-1"
SQ SEQUENCE 597 AA; 69355 MW; F53A9AD8E98EF5E7 CRC64;
MSMGDPLTKV QHSKNIKHER RQSIIVCIEL SSRVYQSSEI SPKAQLAEML EALLELMKQL
AMLLPNSEVC CYVYQCRRLN VKDGIYELLP LEMVNVQKIH KISQLLSDIK NKKMFLKDEI
PFEEIDGSPL SSVLAKIQHQ LQGKTTDEWK FRNKRIILIT ANDMPAEYFD AELQKKFKNT
INALYDDSFS IVTFFIHSQT RPFNDTFYAD LLKPLRRPED LDKNIQYYDG PNTKPIEIKE
LKGKLLQKKE GNKFHFKCAF IINKQNDFII SLKGFFAITQ EKAGERFKYI YQKGAKPQDA
FSHRKFYNAN DGEAADSRLT KVFDIGGLNI EFTEEQDQKM INSFSEHETF LELIGFRSVD
KVNFYYNNIS TSSYVIPDDN VYEGSSKTLS HLYASMTKKG KAAIVWGKLT RIAHPQLFLM
VAMDRKNTNQ GFYLVRLPFI EEIRRFPQTL QKNRSVNIQE YALMKKITGN IIAFFNLKSS
YRAAEFPSPV LKSFYTTLSD KLLQKSLSDQ WGMGFKLSND ITLGKVQHLR ELINKSSQNM
EQPILAKYMK YWNTYYNKEG NNSITNRKKL YQIYSGDPQV QKSMRIRATN AKSVFNL
//
