ID G8JTC7_ERECY Unreviewed; 498 AA.
AC G8JTC7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 03-MAY-2023, entry version 43.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN OrderedLocusNames=Ecym_4213 {ECO:0000313|EMBL:AET39280.1};
OS Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 /
OS NRRL Y-17582) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=931890 {ECO:0000313|EMBL:AET39280.1, ECO:0000313|Proteomes:UP000006790};
RN [1] {ECO:0000313|Proteomes:UP000006790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582
RC {ECO:0000313|Proteomes:UP000006790};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR EMBL; CP002500; AET39280.1; -; Genomic_DNA.
DR RefSeq; XP_003646097.1; XM_003646049.1.
DR AlphaFoldDB; G8JTC7; -.
DR STRING; 931890.G8JTC7; -.
DR GeneID; 11469406; -.
DR KEGG; erc:Ecym_4213; -.
DR eggNOG; KOG2260; Eukaryota.
DR HOGENOM; CLU_033261_1_0_1; -.
DR InParanoid; G8JTC7; -.
DR OMA; ITTKDHQ; -.
DR OrthoDB; 1329460at2759; -.
DR Proteomes; UP000006790; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000006790}.
FT DOMAIN 2..183
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 186..370
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 387..486
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
SQ SEQUENCE 498 AA; 57759 MW; 79CC38CB84F0D73B CRC64;
MAIDYSKWDK IEISDDSDIE VHPNVDKRSF IKWKQQSIHE QRAKRNQDIK NLEFQVEMYN
HLNKRVDKLM SQLSDTDLLS MDVVSRFLNE NFDKNERGSG ENVDPDMPPY NEMVEDLFEQ
LKMNAKDENK NPNDGTVIRE MMEKHREKIT KVTSEAKVKL QELYKEKALH ISSDDIHTGF
DRSIINKNSG EDNESAQYIP KTASSESANS IPKSILANQL MEFIDYKDDT MKLAPETEKF
GSIPWIEYKK SEKFLLEHLP ILSEQQKDAL MMKAFEYQMG GDEKMAYQVI HQSELMSYIR
EIYSMKKIPN LHVRELTEVI NMFFEKVFYK NTGASGKRSF LDSVNSKFEH VKQRCKVLEK
EQATEAAEGG VETIQLKSLD DSTELKVNIP DFESKDPQEQ QKVQAFYKLP KNMQEAVKTQ
SLDAINEVFA SMPIEEAESI LDVFNESEII GINALLEDEN EFKELQEHYN NEKNMETLSI
DKEKNDNITL GDSSNIVD
//
