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Database: UniProt
Entry: G8NDZ1_9DEIN
LinkDB: G8NDZ1_9DEIN
Original site: G8NDZ1_9DEIN 
ID   G8NDZ1_9DEIN            Unreviewed;       214 AA.
AC   G8NDZ1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE            EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN   ORFNames=TCCBUS3UF1_13500 {ECO:0000313|EMBL:AEV16392.1};
OS   Thermus sp. CCB_US3_UF1.
OC   Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=1111069 {ECO:0000313|EMBL:AEV16392.1, ECO:0000313|Proteomes:UP000005635};
RN   [1] {ECO:0000313|EMBL:AEV16392.1, ECO:0000313|Proteomes:UP000005635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCB_US3_UF1 {ECO:0000313|EMBL:AEV16392.1,
RC   ECO:0000313|Proteomes:UP000005635};
RA   Teh B.S., Abdul Rahman A.Y., Saito J.A., Hou S., Alam M.;
RT   "Complete genome sequence of thermophilic Thermus sp. CCB_US3_UF1.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC         Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC         Evidence={ECO:0000256|ARBA:ARBA00001156};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC       biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005010}.
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DR   EMBL; CP003126; AEV16392.1; -; Genomic_DNA.
DR   RefSeq; WP_014515749.1; NC_017278.1.
DR   AlphaFoldDB; G8NDZ1; -.
DR   STRING; 1111069.TCCBUS3UF1_13500; -.
DR   KEGG; thc:TCCBUS3UF1_13500; -.
DR   PATRIC; fig|1111069.3.peg.1323; -.
DR   eggNOG; COG1648; Bacteria.
DR   HOGENOM; CLU_011276_8_1_0; -.
DR   OrthoDB; 9773765at2; -.
DR   UniPathway; UPA00262; UER00222.
DR   Proteomes; UP000005635; Chromosome.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR028161; Met8.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR019478; Sirohaem_synthase_dimer_dom.
DR   InterPro; IPR006367; Sirohaem_synthase_N.
DR   NCBIfam; TIGR01470; cysG_Nterm; 1.
DR   PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR   Pfam; PF10414; CysG_dimeriser; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:AEV16392.1};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Transferase {ECO:0000313|EMBL:AEV16392.1}.
FT   DOMAIN          150..189
FT                   /note="Sirohaem synthase dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF10414"
SQ   SEQUENCE   214 AA;  23819 MW;  D6B3A09C251CC28A CRC64;
     MGYFPLMLDL RGKPVLLVGG GPETPQKLRA LLEAGAEVTV LAQEDPGDLE ALAQEGRIRW
     VRRGYRRGDL EGFFLVVSHP KDKAIHPEVR REAEERRIFL VAVDDPENAS AILPAVLRRG
     ELVVALSTSG AAPALAVRLK ERFAALLPLA YGELVAYLRT LRPRIAQIPD FEARKRLWYR
     IVDQALEALD LDPKEGLPKA MAKAEAALEE VWTR
//
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