ID G8NVI2_GRAMM Unreviewed; 811 AA.
AC G8NVI2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Glucosylceramidase {ECO:0000313|EMBL:AEU36563.1};
DE EC=3.2.1.45 {ECO:0000313|EMBL:AEU36563.1};
DE Flags: Precursor;
GN OrderedLocusNames=AciX8_2245 {ECO:0000313|EMBL:AEU36563.1};
OS Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Granulicella.
OX NCBI_TaxID=682795 {ECO:0000313|EMBL:AEU36563.1, ECO:0000313|Proteomes:UP000007113};
RN [1] {ECO:0000313|EMBL:AEU36563.1, ECO:0000313|Proteomes:UP000007113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1857 / DSM 23137 / MP5ACTX8
RC {ECO:0000313|Proteomes:UP000007113};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S., Mannisto M.,
RA Haggblom M., Woyke T.;
RT "Complete sequence of Granulicella mallensis MP5ACTX8.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003130; AEU36563.1; -; Genomic_DNA.
DR RefSeq; WP_014265441.1; NC_016631.1.
DR AlphaFoldDB; G8NVI2; -.
DR STRING; 682795.AciX8_2245; -.
DR KEGG; gma:AciX8_2245; -.
DR eggNOG; COG4354; Bacteria.
DR HOGENOM; CLU_006322_1_0_0; -.
DR Proteomes; UP000007113; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR InterPro; IPR006775; GH116_catalytic.
DR InterPro; IPR024462; GH116_N.
DR PANTHER; PTHR12654; BILE ACID BETA-GLUCOSIDASE-RELATED; 1.
DR PANTHER; PTHR12654:SF0; NON-LYSOSOMAL GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF04685; DUF608; 1.
DR Pfam; PF12215; Glyco_hydr_116N; 1.
DR PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000313|EMBL:AEU36563.1};
KW Hydrolase {ECO:0000313|EMBL:AEU36563.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007113};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..811
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003513142"
FT DOMAIN 68..386
FT /note="Glycosyl-hydrolase family 116 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12215"
FT DOMAIN 439..803
FT /note="Glycosyl-hydrolase family 116 catalytic region"
FT /evidence="ECO:0000259|Pfam:PF04685"
SQ SEQUENCE 811 AA; 91086 MW; B42E07F9C4BBF697 CRC64;
MKRTSKWIST RGLAFPILAF TLCLSMASTA WGGDGIPKAA WKRALGLPLE NPGVTRAAGD
IDDGYWQGVP VGGFGAGTFS RSYRGDFARW HIKAGVHKYE PVYANQFAMF QQSEGDAHGT
SQALMNGHPS NGELSSWQWD YPVGAGDYYG LFPKAWFDYK WDKFPAHVTL EQFSPVLPNN
YRESSYPVAV YRWHAENPTN KTVVVSVLLS WTNMSGWFRT YTRDFKGAPN QGNHNEYVSE
KVGDAGTMKG IVFDRNRAGT APNDWDGQFA IAAMESPGVE VSYQTTYQAS GDGKAVWSAF
SKDGRLANDG KSWVSDKEKL AGAIALRFTL RPGEKKVVPM VVSWDFSLIQ FGEGRKWDRR
YTDFYGTSGQ NAWKIARDGL LHATEWSDEI DKWQAPYITD ESKPLWYRGM LFNELYALTD
GGTFWGRQAG SDAKATPTFA LLECFDYAYY GTLDVRFYAS LPLLKFWPDI DKQVLREFAD
TVPKEWPEQG LWVWKTQQVG EPITHKRKKI GAVPHDLGVP EGDPFVAVNE PGWQDTNDWK
DLNSKFVLMV YRDYVLTGRK DTAFLRETWP AVKAAIEYLR QFDHGGGVPE NSGYPDQTYD
DWVVRGVSAY SGGLWLAALR AGEETARVVG DTKTTAEYHA LFLKGQKTYI SQLWNGEYFR
YDTSSESKDD IQADQLAGQW YANLTGLGEI VPHTMQVSAA KKIFDVNVMK FGHGEMGAAN
GMTADGAILT NAEAKEVWVG TTLGYAGLLM QEGMNDEAWK TTRGLYHVIY EDKGYWFRTP
EAWDITGNFR AGMYMRPTAI WALEMTSPTA K
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