ID G8NZE6_GRAMM Unreviewed; 161 AA.
AC G8NZE6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN OrderedLocusNames=AciX8_3686 {ECO:0000313|EMBL:AEU37974.1};
OS Granulicella mallensis (strain ATCC BAA-1857 / DSM 23137 / MP5ACTX8).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Granulicella.
OX NCBI_TaxID=682795 {ECO:0000313|EMBL:AEU37974.1, ECO:0000313|Proteomes:UP000007113};
RN [1] {ECO:0000313|EMBL:AEU37974.1, ECO:0000313|Proteomes:UP000007113}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1857 / DSM 23137 / MP5ACTX8
RC {ECO:0000313|Proteomes:UP000007113};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Rawat S., Mannisto M.,
RA Haggblom M., Woyke T.;
RT "Complete sequence of Granulicella mallensis MP5ACTX8.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000256|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000256|HAMAP-
CC Rule:MF_00440}.
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DR EMBL; CP003130; AEU37974.1; -; Genomic_DNA.
DR RefSeq; WP_014266847.1; NC_016631.1.
DR AlphaFoldDB; G8NZE6; -.
DR STRING; 682795.AciX8_3686; -.
DR KEGG; gma:AciX8_3686; -.
DR eggNOG; COG1327; Bacteria.
DR HOGENOM; CLU_108412_0_0_0; -.
DR OrthoDB; 9807461at2; -.
DR Proteomes; UP000007113; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR NCBIfam; TIGR00244; transcriptional regulator NrdR; 1.
DR PANTHER; PTHR30455; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR PANTHER; PTHR30455:SF2; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Metal-binding {ECO:0000256|HAMAP-Rule:MF_00440};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Reference proteome {ECO:0000313|Proteomes:UP000007113};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00440};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Zinc {ECO:0000256|HAMAP-Rule:MF_00440};
KW Zinc-finger {ECO:0000256|HAMAP-Rule:MF_00440}.
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000259|PROSITE:PS51161"
FT ZN_FING 3..34
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00440"
SQ SEQUENCE 161 AA; 18951 MW; E0DB42B50427C7BA CRC64;
MKCPYCAFTQ DKVIDSRESK DANSIRRRRE CERCNKRFTT YERLDEIPYM VVKKDGRREN
FDRQKVLTGL LHSCQKRKVS VTQMQEIVDA VEAFVIDSPE RERTTASVGE LIMARLKDID
TVAYIRFASV YRDFKDVREF KQELEELLGG KDPKSKRLAS R
//
