ID G8QQZ6_SPHPG Unreviewed; 677 AA.
AC G8QQZ6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN OrderedLocusNames=SpiGrapes_2057 {ECO:0000313|EMBL:AEV29844.1};
OS Sphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Sphaerochaetaceae;
OC Sphaerochaeta.
OX NCBI_TaxID=158190 {ECO:0000313|EMBL:AEV29844.1, ECO:0000313|Proteomes:UP000005632};
RN [1] {ECO:0000313|EMBL:AEV29844.1, ECO:0000313|Proteomes:UP000005632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1885 / DSM 22778 / Grapes
RC {ECO:0000313|Proteomes:UP000005632};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Munk A.C., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Ritalahtilisa K.,
RA Loeffler F., Woyke T.;
RT "Complete sequence of Spirochaeta sp. grapes.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; CP003155; AEV29844.1; -; Genomic_DNA.
DR RefSeq; WP_014270685.1; NC_016633.1.
DR AlphaFoldDB; G8QQZ6; -.
DR STRING; 158190.SpiGrapes_2057; -.
DR MEROPS; S16.A10; -.
DR KEGG; sgp:SpiGrapes_2057; -.
DR eggNOG; COG1067; Bacteria.
DR HOGENOM; CLU_014785_0_1_12; -.
DR OrthoDB; 9758568at2; -.
DR Proteomes; UP000005632; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000005632};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 446..641
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 536
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 677 AA; 74646 MW; E54B8FF832CE18E1 CRC64;
MTAMVTTVKE LPYEEACFDF DLEMIHECRK NVSDEGIIGQ PRAIRSLAMG FALEKAGYNI
FVSGNTGSGR LEAVKQMAEK ARMDISHVKD IAYVCNFTQS DSPLALTFSP GKGQEFADAM
EIFSRKLVQL AVEKTNFLEA SSKLVESLEK QFQDKQIVVF LKHLKDDLIR QEPRINTLNE
EKILKDPITG RYRVNLLVNH ADTTLRPLVI ESHPTFSNLF GSVDAHQSNY HLALHAGSLL
EAAGGFIVIN AEELLAETGL WDALKRYLDS NALALEGKCF PKGEMRSGGI RPQMAPISVK
VILIGSEDTF DTLTEHDERF LGLFKISAQF DYSMAATAEN IAKTISVLTR YAEKNNLLPL
SDDALSQMLR YSAWFSESRN ELATQFSQLF DVLIEADYWA RAAGKDSIDG AMILKANDER
SYISGISESR INDEILNGEM IISLTGSKTG VVNGLAVMDR GAASFGTPTV ISATVAPGNE
GIVNIEHEAG LSGEIHDKGL LILEGYLRKH YARTFPLSIY AGIAFEQSYA EVDGDSASSS
ELYALLSAIG ELPIRQEIAV TGSVNQMGMI QPVGGINEKI EGFFRTCQAT GLTGKQGVII
PYQNVKNLIL PYEILDAIKN HTFHIYPIKT IDEGMQVLSG RPPGKRNTKG NFTPDNFNYS
IEDRLRKMYQ AVVATRG
//
