ID   G8QXX5_SPHPG            Unreviewed;       553 AA.
AC   G8QXX5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   OrderedLocusNames=SpiGrapes_0638 {ECO:0000313|EMBL:AEV28480.1};
OS   Sphaerochaeta pleomorpha (strain ATCC BAA-1885 / DSM 22778 / Grapes).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Sphaerochaetaceae;
OC   Sphaerochaeta.
OX   NCBI_TaxID=158190 {ECO:0000313|EMBL:AEV28480.1, ECO:0000313|Proteomes:UP000005632};
RN   [1] {ECO:0000313|EMBL:AEV28480.1, ECO:0000313|Proteomes:UP000005632}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1885 / DSM 22778 / Grapes
RC   {ECO:0000313|Proteomes:UP000005632};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Munk A.C., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Ritalahtilisa K.,
RA   Loeffler F., Woyke T.;
RT   "Complete sequence of Spirochaeta sp. grapes.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006637}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003155; AEV28480.1; -; Genomic_DNA.
DR   RefSeq; WP_014269329.1; NC_016633.1.
DR   AlphaFoldDB; G8QXX5; -.
DR   STRING; 158190.SpiGrapes_0638; -.
DR   KEGG; sgp:SpiGrapes_0638; -.
DR   eggNOG; COG1061; Bacteria.
DR   HOGENOM; CLU_008213_4_0_12; -.
DR   OrthoDB; 9802848at2; -.
DR   Proteomes; UP000005632; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd18789; SF2_C_XPB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR032438; ERCC3_RAD25_C.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032830; XPB/Ssl2_N.
DR   PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF16203; ERCC3_RAD25_C; 1.
DR   Pfam; PF13625; Helicase_C_3; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000313|EMBL:AEV28480.1};
KW   Helicase {ECO:0000313|EMBL:AEV28480.1};
KW   Hydrolase {ECO:0000313|EMBL:AEV28480.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:AEV28480.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005632}.
FT   DOMAIN          209..356
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          410..553
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   553 AA;  62499 MW;  6776979CA96CA17B CRC64;
     MNDKPLIVQS DKTMLLDVHH SEAEACRADL VRFCELIKSP EHVHTYALSA ISLWNAASSG
     VTSEEICEKL TFWSRFPISE SVLFYINDIA SRFGKVVLTE SEDPQYYQLE VKTERIRSEI
     MARKAIAKLM IVKSNRSFLI EKYNRGEVKL QLIKMGYPVD DRIVLEKGIP VEMAMCEKTK
     GGKTFSVRPY QTQAAQALLG DQGPGCGYGT IVLPCGSGKT VVGMTIMSQL KTRTLIVTTN
     VAAVHQWISE ILDKMTLTQQ QIGEYTGEKK DPREVTVCTY QVLTYRPDKD GPFPHLELLT
     KGQWGLIIYD EVHMLPAPVF KITAELQAVY RVGLTATLVR EDGREDEVFS LVGPKRFDVP
     WNELQQQGFI ATAYCSEIRL DLPTDMEIPY AIANKREKYR IASENPLKLD VVKGLVARHP
     DDYILIIGQY IKQLESIAAE FKLPIITGST PNAKREELYR AFKEGESHIL VVSKVANFAI
     DLPDASVAIQ VSGTFGSRSE EAQRLGRILR PKNRSSFFYS VVTRYSTEEE FAANRQKFLA
     EQGYSYDIEV WEN
//