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Database: UniProt
Entry: G8R3D0_OWEHD
LinkDB: G8R3D0_OWEHD
Original site: G8R3D0_OWEHD 
ID   G8R3D0_OWEHD            Unreviewed;       476 AA.
AC   G8R3D0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Oweho_0941 {ECO:0000313|EMBL:AEV31951.1};
OS   Owenweeksia hongkongensis (strain DSM 17368 / CIP 108786 / JCM 12287 /
OS   NRRL B-23963 / UST20020801).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Cryomorphaceae; Owenweeksia.
OX   NCBI_TaxID=926562 {ECO:0000313|EMBL:AEV31951.1, ECO:0000313|Proteomes:UP000005631};
RN   [1] {ECO:0000313|EMBL:AEV31951.1, ECO:0000313|Proteomes:UP000005631}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 17368 / JCM 12287 / NRRL B-23963
RC   {ECO:0000313|Proteomes:UP000005631};
RX   PubMed=23450211; DOI=10.4056/sigs.3296896;
RA   Riedel T., Held B., Nolan M., Lucas S., Lapidus A., Tice H.,
RA   Del Rio T.G., Cheng J.F., Han C., Tapia R., Goodwin L.A., Pitluck S.,
RA   Liolios K., Mavromatis K., Pagani I., Ivanova N., Mikhailova N.,
RA   Pati A., Chen A., Palaniappan K., Rohde M., Tindall B.J., Detter J.C.,
RA   Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Genome sequence of the orange-pigmented seawater bacterium
RT   Owenweeksia hongkongensis type strain (UST20020801(T)).";
RL   Stand. Genomic Sci. 7:120-130(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP003156; AEV31951.1; -; Genomic_DNA.
DR   RefSeq; WP_014201312.1; NC_016599.1.
DR   STRING; 926562.Oweho_0941; -.
DR   EnsemblBacteria; AEV31951; AEV31951; Oweho_0941.
DR   KEGG; oho:Oweho_0941; -.
DR   PATRIC; fig|926562.3.peg.954; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; 219876at2; -.
DR   BioCyc; OHON926562:G1H1R-931-MONOMER; -.
DR   Proteomes; UP000005631; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005631};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005631}.
FT   DOMAIN      172    302       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      383    452       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     180    187       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   476 AA;  54195 MW;  B49EEF824A77F42C CRC64;
     MELTAKTVWG NCLDYIKDNI PTQSFKTWFL PIKPLKLKDN VLSIQVPSKF FYEWLEENYI
     KLLKSAITRE LGEDAKLVYS IVMENTYGNA NPYTVKIPSS NRAPIKNPKV SMPVDIGDKG
     VKNPFIIPGL RKVHVESQLN PNYTFDNFVE GDCNRLARSA GYAVSNKPGG TSFNPLLIYG
     GNGLGKTHLA HSIGIEIKDK YPEKTVLYVS AEKFTQQFID AIRNNTKNDF VHFYQMIDIL
     IMDDVHSFAG KEKTQDVFFE IFNHLHQHGK QVILTSDRAP VDLQGMEQRL LSRFKWGLSA
     DLQVPDLETR IAILHQKLYN DGVEMPADVI EYLAYSINSN VRELEGALIS LLAQSSLNKK
     KITVELAKQM IDKFVKNTTR EISIDYIQKV VCDYFDMPID LLKSPTRKRE IVQARQLAMY
     FSKQLTKASL ASIGAQCGNK DHATVLHACR TVNNLAETDK RFKNYVEDLR KKLTLQ
//
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