ID   G8R3E4_OWEHD            Unreviewed;       803 AA.
AC   G8R3E4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit {ECO:0000313|EMBL:AEV31965.1};
GN   OrderedLocusNames=Oweho_0955 {ECO:0000313|EMBL:AEV31965.1};
OS   Owenweeksia hongkongensis (strain DSM 17368 / CIP 108786 / JCM 12287 / NRRL
OS   B-23963 / UST20020801).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Owenweeksiaceae;
OC   Owenweeksia.
OX   NCBI_TaxID=926562 {ECO:0000313|EMBL:AEV31965.1, ECO:0000313|Proteomes:UP000005631};
RN   [1] {ECO:0000313|EMBL:AEV31965.1, ECO:0000313|Proteomes:UP000005631}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 17368 / JCM 12287 / NRRL B-23963
RC   {ECO:0000313|Proteomes:UP000005631};
RX   PubMed=23450211; DOI=10.4056/sigs.3296896;
RA   Riedel T., Held B., Nolan M., Lucas S., Lapidus A., Tice H., Del Rio T.G.,
RA   Cheng J.F., Han C., Tapia R., Goodwin L.A., Pitluck S., Liolios K.,
RA   Mavromatis K., Pagani I., Ivanova N., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Rohde M., Tindall B.J., Detter J.C., Goker M., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Genome sequence of the orange-pigmented seawater bacterium Owenweeksia
RT   hongkongensis type strain (UST20020801(T)).";
RL   Stand. Genomic Sci. 7:120-130(2012).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP003156; AEV31965.1; -; Genomic_DNA.
DR   RefSeq; WP_014201326.1; NC_016599.1.
DR   AlphaFoldDB; G8R3E4; -.
DR   STRING; 926562.Oweho_0955; -.
DR   KEGG; oho:Oweho_0955; -.
DR   PATRIC; fig|926562.3.peg.968; -.
DR   eggNOG; COG0022; Bacteria.
DR   eggNOG; COG1071; Bacteria.
DR   HOGENOM; CLU_350462_0_0_10; -.
DR   OrthoDB; 9769337at2; -.
DR   Proteomes; UP000005631; Chromosome.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:AEV31965.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005631}.
FT   DOMAIN          470..644
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   803 AA;  89770 MW;  DEE1E4700AD13DB1 CRC64;
     MSDTRTQSDK QLTFEEFKEG VINDYKLAIE SREASLIGRR EVLTGKAKFG IFGDGKEVAQ
     IAWSKVFKNG DFRAGYYRDQ TFMMAIGQLT TQQFFASLYA DTNHENEPAS AGRQMNGHFT
     TQSLDENGNW KDLTAQKNSS ADISPTAGQM PRLLGLAEAS KVYRENKDLK DFTNFSKNGN
     EIAWGTIGNA STSEGLFFET FNAAGVLQVP MVISVWDDDY GISVHAKYQT TKENISEILK
     GFQKDEDTNG FEILNVKGWD YPSLVETYEK AEKIAREQHV PVLIHVNEIT QPQGHSTSGS
     HERYKNEQRL KWEQEFDCIK KMREWMIMSA VATEEELVDI EKAAKKVARE AKTAAWSNFI
     NPIKEEVNTV VGMIEAAAAK SSNSEEISAM AATLKSTMDP LRKDAISAAR RAVWALRNDG
     DASAELKNWL EAENVKNKDR YNDYLYSQSD LSPLRIEEVA PIYSDDSKEV DARIILKENF
     DRLLTEKPEV LIFGEDSGKI GDVNQGLEGL QEKHGEGRVF DTGIREATIM GQGIGMAMRG
     LRPIAEIQYL DYLLYALQIM SDDLATVHYR TKGRQKAPVV IRTRGHRLEG VWHSGSPMGS
     IINTVRGVHV LVPRNMTKAA GFYNTMLESD DPALIVECLN GYRLKERTPD NLSEIRTPLG
     VVETIREGSD LTLVTYGSSC RIAMDAANLL EEMGIDMQVI DVQSLLPFDR NHDIVKSLAN
     TNRLVVMDED VPGGASAFIM QQVLEEQGGY KHLDSKPLSI TAKAHRPAYG TDGDYFSKPS
     ADDIVEQVYA MMHEADPTRF PAI
//