ID G8RIE3_MYCRN Unreviewed; 497 AA.
AC G8RIE3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN OrderedLocusNames=MycrhN_4156 {ECO:0000313|EMBL:AEV74658.1};
OS Mycolicibacterium rhodesiae (strain NBB3) (Mycobacterium rhodesiae).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=710685 {ECO:0000313|EMBL:AEV74658.1, ECO:0000313|Proteomes:UP000005442};
RN [1] {ECO:0000313|EMBL:AEV74658.1, ECO:0000313|Proteomes:UP000005442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBB3 {ECO:0000313|EMBL:AEV74658.1,
RC ECO:0000313|Proteomes:UP000005442};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Gu W., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A.,
RA Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of Mycobacterium rhodesiae NBB3.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003169; AEV74658.1; -; Genomic_DNA.
DR RefSeq; WP_014212408.1; NC_016604.1.
DR AlphaFoldDB; G8RIE3; -.
DR STRING; 710685.MycrhN_4156; -.
DR KEGG; mrh:MycrhN_4156; -.
DR PATRIC; fig|710685.3.peg.4168; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000005442; Chromosome.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005442}.
FT DOMAIN 20..477
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 497 AA; 52567 MW; 47A6BC59109BF971 CRC64;
MSKTISHWIN NEVFAGAGTN TAPVTNPATG AVTGEVALAS VGDARAVIDA AAAAFPAWRD
TSLAKRTQIL FNFRELLNAR KDKLAEIITS EHGKVVSDAL GEVSRGQEVV EFACGIPHLL
KGGFTENAST KVDVYSIRQP LGVVGVISPF NFPAMVPMWF FPIAIATGNT VVLKPSEKDP
SASLWIAELW KEAGLPPGVF NVLQGDKTAV DELLTDSKVK SVSFVGSTPI AQYVYATGTA
HDKRVQALGG AKNHAVILPD ADLDLAADAM VNAGFGSAGE RCMAISACVA VGPIADDLVA
KIAERAADIK TGDGTRDSDM GPLVTKAHRD KVASYIDAGE ADGAKIVVDG RNVKADGGQE
GFWLGPTLID NVTPEMSIYT DEIFGPVLSV LRVESYDEAM DLVNSNPYGN GTAIFTNDGG
AARRFQNEVQ VGMVGINVPI PVPMAYYSFG GWKASLFGDS HAHGMDGVQF FTRQKAITSR
WLDPSHGGIE LGFPQNQ
//
