ID G8RSK4_MYCRN Unreviewed; 486 AA.
AC G8RSK4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II {ECO:0000313|EMBL:AEV76537.1};
GN OrderedLocusNames=MycrhN_6075 {ECO:0000313|EMBL:AEV76537.1};
OS Mycolicibacterium rhodesiae (strain NBB3) (Mycobacterium rhodesiae).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=710685 {ECO:0000313|EMBL:AEV76537.1, ECO:0000313|Proteomes:UP000005442};
RN [1] {ECO:0000313|EMBL:AEV76537.1, ECO:0000313|Proteomes:UP000005442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBB3 {ECO:0000313|EMBL:AEV76537.1,
RC ECO:0000313|Proteomes:UP000005442};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Gu W., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A.,
RA Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of Mycobacterium rhodesiae NBB3.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003169; AEV76537.1; -; Genomic_DNA.
DR RefSeq; WP_014214274.1; NC_016604.1.
DR AlphaFoldDB; G8RSK4; -.
DR STRING; 710685.MycrhN_6075; -.
DR KEGG; mrh:MycrhN_6075; -.
DR PATRIC; fig|710685.3.peg.6100; -.
DR eggNOG; COG0318; Bacteria.
DR HOGENOM; CLU_000022_59_0_11; -.
DR OrthoDB; 3444674at2; -.
DR Proteomes; UP000005442; Chromosome.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:AEV76537.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005442}.
FT DOMAIN 15..351
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 400..470
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 486 AA; 52261 MW; D6386530E561BD0B CRC64;
MAAHPLSRRI RDVLNLRPDG PAVEFDGAWL TRSEVAELAR RIESLDSADR QVGILLRNTP
AHIAAFLGVL MGGGTVVVIN PSRGDDRIRS HIESLRLPII IGTIDDLKTL VVSTAQTATV
AIAGLDDPPV VTAAEQPAED TGRAGVAVRM LTSGTTGPPK RIDLTYDMLA RSVIGTDFDV
APSPTEARRG VAIVNAPLVH IGGVFRVLQC VCEARPFALL DRFELQRWTD AVRRHRPQAV
SLVPAALRTV LHSDLTRDDL KSIRAVTSGT APLSAEDADA FTDKFGIPVL TSYAATEFGG
GVAGWTLADY QTYWHTKRGS VGRATLGAHL RVVDDNGAPV GDDQPGLLEV KPGQLGPSGG
WMRTTDLARI DADGFLWILG RADQAIIRGG FKVMPDDVRS ALETHPAVQG AAVVGRSDPR
LGETPVAMVE LRESADVDTL LEYLRTRLAR YEIPTEIAIV EQIPRTPSGK ADLTAVREHF
TTVEHA
//
