ID G8S1H6_ACTS5 Unreviewed; 370 AA.
AC G8S1H6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=PTS system, mannitol-specific IIA component {ECO:0000313|EMBL:AEV87254.1};
DE EC=2.7.1.69 {ECO:0000313|EMBL:AEV87254.1};
GN Name=mtlA {ECO:0000313|EMBL:AEV87254.1};
GN OrderedLocusNames=ACPL_6372 {ECO:0000313|EMBL:AEV87254.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV87254.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003170; AEV87254.1; -; Genomic_DNA.
DR RefSeq; WP_014693320.1; NZ_LT827010.1.
DR AlphaFoldDB; G8S1H6; -.
DR STRING; 134676.ACPL_6372; -.
DR KEGG; ase:ACPL_6372; -.
DR PATRIC; fig|134676.3.peg.6258; -.
DR eggNOG; COG2213; Bacteria.
DR HOGENOM; CLU_028721_2_0_11; -.
DR OrthoDB; 9814222at2; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0103111; F:D-glucosamine PTS permease activity; IEA:UniProtKB-EC.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013014; PTS_EIIC_2.
DR Pfam; PF02378; PTS_EIIC; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000313|EMBL:AEV87254.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 87..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..349
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000259|PROSITE:PS51104"
SQ SEQUENCE 370 AA; 38286 MW; D85424A1C307332A CRC64;
MASTYTPEVT GGGFRAAVQK LGGHLAGMVM PNIGALIAWG LITALFIPVG WIPNANLAQL
VDPMIKYLLP VLIGYTGGRL VHGQRGAVVG AIATFGVVVG ADVPMFLGAM IIAPLTAYVL
RLFDGAIEGR IRPGFEMLVD NFSAGIIGAG FAILGKLAIG PVVDGLTKAA GNAVDWLLAH
SLMPLASILV EPAKVLFLNN AINHGVFGPL GVQQVQEHGK SILFMIESNP GPGLGLLTAY
LFFGPKSLRP SAPAAMIIHF LGGIHEIYFP YVLMKPRLIL AMIAGGMSGV ATFMITGTGT
VATPAPGSIF AYFAVTAKSG YLGMILGVTI AAAVTFAVAS ALLGFGRLKS DQELDEQAEP
APAEVAPQQA
//
