ID G8S6Y9_ACTS5 Unreviewed; 2341 AA.
AC G8S6Y9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Peptide synthase {ECO:0000313|EMBL:AEV85018.1};
DE EC=6.1.1.13 {ECO:0000313|EMBL:AEV85018.1};
GN OrderedLocusNames=ACPL_4123 {ECO:0000313|EMBL:AEV85018.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV85018.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003170; AEV85018.1; -; Genomic_DNA.
DR RefSeq; WP_014691090.1; NZ_LT827010.1.
DR STRING; 134676.ACPL_4123; -.
DR KEGG; ase:ACPL_4123; -.
DR PATRIC; fig|134676.3.peg.4039; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_4_11; -.
DR OrthoDB; 5476914at2; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:AEV85018.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440}.
FT DOMAIN 965..1039
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1996..2071
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2341 AA; 252973 MW; E0DB79595AFD74AC CRC64;
MTETMDPASL RAELMRRRLS GVTAPRPAAG PRPADRSAPI PLSYAQQRLW LLDQLQPGTT
EYLASTVLRL TGPLDEPALR RALDTLVARH EVLRTRYPLR DGDPVQVIDD PAPVDLTRLD
LRALDRARAE ARLAALGTTD RQPVDLADGP VLRATLARLG PHEHALALTI HHIATDGWSD
GLLVDELIRL YAGHRFPGPP ALQYADVALW QRTGAPLDEH LAFWRDRLAG LVPVELPADR
PRPPVRDPAG AFLPFVIPAP VARKLSELAR RRGATTFQAA LAGYLILLSR YTGLDDIAVG
TTVAGRDHPQ VQDLPGLFVN TVVLRADLSG SPSYSDVLDR VRDVTLDAHA HQDLPFERLV
EELAPGRDPS RTPLFSTMFL MDDTPATVRE AGGLRFERIP VGESSAKFDL TVAIAERPDG
SLAGGITYAT ALFDRATVER LAGHLGQLLA GAVADPRSPA DRLDLLTAGE LRQLTRGGNG
SVQTYPGGTL PALLEAQAAG TPTATALRYE GREWTYAEVN ARANRIAHHL RGLGAGPESV
VAVELPRGAD LVFALLGVLK AGAAYLPLDP EHPADRRAFM AQDAGARIVV TERLLADAEG
GDDSDPVSGV TPAHAAYVIY TSGSTGRPKG VLIEHRAIVN RLQWMQQTYR LDAGDRVLQK
TPAGFDVSVW EFFWPLLTGA TLVVARPGGH RDPAYLAALI AAERITTLHF VPSMLRAFLA
EPCGTLPSVR RIICSGEALP ADLADAVHER IGGELHNLYG PTETAVDVTA LRCLPGEPVT
IGRPIANTSA YIVDDRGRPQ PVGVPGELLI GGVQVARGYI GRPGLTADRF VPDPFGADPG
GRLYRTGDLA RHRPDGTIEY LGRLDHQVKI AGQRIELGEV ETVLRECPGV TDAAAAVADG
QLVGYVVTDT SVDDIRAHLR RRLPEAMIPA RWAVLAALPL TGSGKLDRRA LPDPDAPVPT
GAYDAPHGEV ENLLAGEFGA ALGIAKVGRH DSFFQLGGDS MRAIRVVGAA RAAGIALRVQ
DMFTHQSVAA LAELTGSRAE SSPERPVEPF TQISDADRRL LPPGLSDAYP ITQNQAGMLY
EMLSGADRAV YRNVSCYRIR DGKPFAAGAL EQALRLLLVR HEILRTSFDL GTYSEIMQLV
HERAELPVEV RDLRGRPAAD QQDAVRSFLA AEREVPFDIG RAPLVRYTVH LLSDQEWLLT
HAECHAILDG WSHTATVAML IDLYRGVRDG TPPELPAPPG VRFADFVHLE RAALDSTEDR
EFWAATVASR DRFELPPEWA TEPAGAPATI VDVPWADLAP GLKRLAAAAN ASLKSVLHAA
HLKALSVATG QERFFDGLLC NGRPERLRGD EVFGMYLNTV PFAADTRART WRELVAGVFA
EEARLWPHRR YPQPTMQRDW GSASRLIEVA FGYLDFHVLA GEAESGVRMI DDFSPGSLAL
EVWTFPGVLR LGADPARIGR PHLELLRRTY RHVLEAMAAD PGGDARAVGL AAADRHDAVD
RFQNPVAFPA LPLLHDLVPT GAAVALRQGD RTLSYDEVHA LAGGLAARLH RLGVGPDTVV
GLLLPRGTDL VVAMLAVLRA GGAFLPLDPA YPAERIRYML DDAAPAVVLT DPAYAALAPG
AEIVDHEAYR TLPAAPPPAL NGENLAYVIY TSGSTGRPKG VGVPHRALLN LRHAQNRHLD
VRPGDRVLQF ASPSFDASVW ELAMALTNGA ALVLPPPGTD PGDLRAQAGV VTHMTVPPSL
LDRLRPDDFP HLRVLVTAGE AVTAEQVARW APHTRVVNGY GPTETAVCAA AAELGTSAPA
GPPPIGQPFA NARVYVLDHD QRPLPAGVRG ELVVGGAGVS RGYLGRPALT AERFVPDPYA
TVPGQRMYRT GDVASRSAEG TLSFHGRRDH QVKVRGFRIE LGEVEHALAA CPGVTGAVCT
VHRPGTPDAT LVAYTRGGVP AADLRAHLAD RLPQHLIPTH FRAVDDFPLT PAGKVDRAAL
PAPDGSRPAT GAAYTAPRTD RERHLAQAWS EALGVARIGA DDDFFDLGGH SLAMMRVIAA
LRSRHGYELT FRSFLEQRTV ARLAATLTEQ SSGRALMWLR DGTGRVPLIC VHPGGGSAHW
YQRLLPHLHP EQPVAAFEWP GPHPQGTPST EQMAARYLAE LRDARLEGPY RILSWCGGSG
IAMEMAHRLI DAGEQVTVML LDPGLDMHSR DDGWSELALM RRLEALLAEG ADTPQRRTEI
LSLLDHLVDD VDPATGIVLP EGGAGHWPAA VRIWREVMEM DMSYRHRVFP GRLELIASDE
LVRGEHEVAS GQSYGDYLAR WRELVTGGVR VHRVPGDHFS VLREPHVRRF AELITGLLDD
A
//