ID G8S9Y6_ACTS5 Unreviewed; 631 AA.
AC G8S9Y6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN Name=lctP {ECO:0000313|EMBL:AEV83889.1};
GN OrderedLocusNames=ACPL_2994 {ECO:0000313|EMBL:AEV83889.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV83889.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; CP003170; AEV83889.1; -; Genomic_DNA.
DR RefSeq; WP_014689961.1; NZ_LT827010.1.
DR AlphaFoldDB; G8S9Y6; -.
DR STRING; 134676.ACPL_2994; -.
DR KEGG; ase:ACPL_2994; -.
DR PATRIC; fig|134676.3.peg.2913; -.
DR eggNOG; COG1620; Bacteria.
DR HOGENOM; CLU_021628_0_0_11; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 46..67
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 175..194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 214..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 237..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 266..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 390..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 445..465
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 486..503
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 509..532
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 602..629
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT REGION 344..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 64355 MW; 93931AF084A2F7AD CRC64;
MADQIIAGGF RIVVDPVSDS VRLSAIFAVL PLLTLFLLLG VFRVRAWLAG VISLVVALVV
AIAGYAMPVG QALLSASEGA AFGFFPILWI VINAIWVYNL TVVSGHFDVL RRSMERVSPD
MRIQAIIVAF CFGALLEALA GFGTPVAVTV VMLTALGFAP IRAASVALIA NTAPVAFGAL
ATPIVTLATV TSGAGNDPRL TTDTLGAMVG RQTPVLALVV PLILVFVVDG RRGVRQAWPA
AAVAGLVFAV AQFVASNHLS VPLTDIVASL AAAAAVVLLL RLWQPARAVG SSPLTGAAAR
RDASAGDGAL TGTVARRDAS AGDGALTGTV ARRDASAGDG ALTGTVARRD ASAGEGPPTG
TAQRRDVAVE GSLLSGTGLR RDAPAEVARA YAPYLIIIVI FAIANLGPVK SALARSPWTV
IFAWPGLHVL SATGKPLSST NFTLGWLPAA GTLLIIAGIL SAVVLRVRPG AAARAYGRTY
AELRQPIVTV MAVLALAYVL NQSGQTNTLG AFLATAGGVF VFLSPILGWI GVAVTGSDTS
ANALFGALQV QTAAKAGLDP LLLAAANSSG GVLGKMVSPQ NLAIAAGAVG MAGREGDIFR
KVILWSAVLL LGMCVLVTLQ STPILGWMIP G
//
