ID G8SB43_ACTS5 Unreviewed; 548 AA.
AC G8SB43;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=ACPL_526 {ECO:0000313|EMBL:AEV81423.1};
OS Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV81423.1, ECO:0000313|Proteomes:UP000005440};
RN [1] {ECO:0000313|Proteomes:UP000005440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC {ECO:0000313|Proteomes:UP000005440};
RA Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA Wehmeier U.F., Stoye J., Puehler A.;
RT "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT SE50/110.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP003170; AEV81423.1; -; Genomic_DNA.
DR RefSeq; WP_014687502.1; NZ_LT827010.1.
DR AlphaFoldDB; G8SB43; -.
DR STRING; 134676.ACPL_526; -.
DR KEGG; ase:ACPL_526; -.
DR PATRIC; fig|134676.3.peg.412; -.
DR eggNOG; COG1061; Bacteria.
DR HOGENOM; CLU_008213_4_0_11; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000005440; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AEV81423.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005440}.
FT DOMAIN 190..344
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 398..546
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 548 AA; 60532 MW; EE265F1A6258F49D CRC64;
MNGGPLIVQS DKTLLLEVDH PDAQACRMAI APFAELERSP EHVHTYRLTP LGLWNSRAAG
HDAESVVDAL ITYSRYPVPH ALLVDVAETM DRYGRLQLLN DPVHGLVLRG LDRIVLLEVS
KSKKLAGMLG ARLDDETIAV HASERGRLKQ ALLKLGWPAE DLAGYVDGEA HPIELRQDGW
TLRSYQQEAV DGFWAGGSGV VVLPCGAGKT LVGAAAMATA KATTLILVTN TVAGRQWKRE
LIARTTLTEE EIGEYSGERK EIRPVTIATY QVLTARRGGN FTHLDLFGAR DWGLVVYDEV
HLLPAPIFRF TADLQARRRL GLTATLVRED GREGDVFSLI GPKRYDAPWK DIEAQGWIAP
AECVEVRVTL TEQERMAYAV TDAEERYKAA ATARTKLPVV KALVARHPQE QVLVIGGFLD
QLHTLGEYLD APIVEGSTSN KERERLFDAF RSGELRTLVL SKVGNFSIDL PEAAVAIQVS
GTFGSRQEEA QRLGRVLRPK GDGRQAHFYS VVSRDTIDTE YAAHRQRFLA EQGYAYTIVD
ADDVLQVD
//
