ID   G8SHB6_ACTS5            Unreviewed;       373 AA.
AC   G8SHB6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=IMP dehydrogenase {ECO:0000313|EMBL:AEV81767.1};
DE            EC=1.1.1.205 {ECO:0000313|EMBL:AEV81767.1};
GN   OrderedLocusNames=ACPL_870 {ECO:0000313|EMBL:AEV81767.1};
OS   Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV81767.1, ECO:0000313|Proteomes:UP000005440};
RN   [1] {ECO:0000313|Proteomes:UP000005440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC   {ECO:0000313|Proteomes:UP000005440};
RA   Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA   Wehmeier U.F., Stoye J., Puehler A.;
RT   "The complete genome sequence of the acarbose producer Actinoplanes sp.
RT   SE50/110.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family.
CC       {ECO:0000256|ARBA:ARBA00005502}.
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DR   EMBL; CP003170; AEV81767.1; -; Genomic_DNA.
DR   RefSeq; WP_014687840.1; NZ_LT827010.1.
DR   AlphaFoldDB; G8SHB6; -.
DR   STRING; 134676.ACPL_870; -.
DR   KEGG; ase:ACPL_870; -.
DR   PATRIC; fig|134676.3.peg.759; -.
DR   eggNOG; COG0516; Bacteria.
DR   HOGENOM; CLU_064068_0_0_11; -.
DR   OrthoDB; 9805398at2; -.
DR   Proteomes; UP000005440; Chromosome.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR005992; IMP_DH-rel2.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   NCBIfam; TIGR01304; IMP_DH_rel_2; 1.
DR   PANTHER; PTHR11911:SF85; INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR11911; INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   SMART; SM01240; IMPDH; 1.
DR   SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:AEV81767.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005440}.
FT   DOMAIN          17..298
FT                   /note="IMP dehydrogenase/GMP reductase"
FT                   /evidence="ECO:0000259|Pfam:PF00478"
SQ   SEQUENCE   373 AA;  39573 MW;  AE2B5E9F54EFFDB5 CRC64;
     MRDVVEIGLG KTAQRGYHLD DIAIVPSRRT RDVDDVSTEW KLDAYPFKIP CVAHPSDATQ
     SPDSVIALGR LGGLGVLNAE GLWTRYEDPS KILEELASLD EEADATKRLQ EVYAEPIKPE
     LIGERVRQIR EGGVTVAVRV SPQHTLALAP VILDAGVDLL VIQGTLVSAE HVSTTDEPLN
     LKEFIADLDL PVIVGGCTDY KTALHLMRTG AAGVIVGVGA DEWSTTDTVL GIRVPMATAI
     ADAAAARRDY LDETGGRYVH LIADGGIATS GDIAKAIGCG ADAVMLGEPL SLAEGAPAGG
     AWWHSAASHP ALPRGGFCIA GEPDGSLEQL LYGPADRADG QLNLFGGLRR AMAKCGYRDV
     KEFQKVALVL DRQ
//