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Database: UniProt
Entry: G8SI02_ACTS5
LinkDB: G8SI02_ACTS5
Original site: G8SI02_ACTS5 
ID   G8SI02_ACTS5            Unreviewed;       497 AA.
AC   G8SI02;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Multi-sensor signal transduction histidine kinase {ECO:0000313|EMBL:AEV85618.1};
DE            EC=2.7.3.- {ECO:0000313|EMBL:AEV85618.1};
GN   OrderedLocusNames=ACPL_4727 {ECO:0000313|EMBL:AEV85618.1};
OS   Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Actinoplanes.
OX   NCBI_TaxID=134676 {ECO:0000313|EMBL:AEV85618.1, ECO:0000313|Proteomes:UP000005440};
RN   [1] {ECO:0000313|Proteomes:UP000005440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31044 / CBS 674.73 / SE50/110
RC   {ECO:0000313|Proteomes:UP000005440};
RA   Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K.,
RA   Wehmeier U.F., Stoye J., Puehler A.;
RT   "The complete genome sequence of the acarbose producer Actinoplanes
RT   sp. SE50/110.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP003170; AEV85618.1; -; Genomic_DNA.
DR   RefSeq; WP_014691689.1; NC_017803.1.
DR   STRING; 134676.ACPL_4727; -.
DR   EnsemblBacteria; AEV85618; AEV85618; ACPL_4727.
DR   KEGG; ase:ACPL_4727; -.
DR   PATRIC; fig|134676.3.peg.4641; -.
DR   eggNOG; ENOG4105BZU; Bacteria.
DR   eggNOG; ENOG410XNMH; LUCA.
DR   OMA; SQTIIQA; -.
DR   OrthoDB; 1755994at2; -.
DR   BioCyc; ASP134676:G1H1W-4622-MONOMER; -.
DR   Proteomes; UP000005440; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR007891; CHASE3.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF05227; CHASE3; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00925949};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005440};
KW   Kinase {ECO:0000256|SAAS:SAAS01003914, ECO:0000313|EMBL:AEV85618.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00925724, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00925310};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005440};
KW   Transferase {ECO:0000256|SAAS:SAAS01003669,
KW   ECO:0000313|EMBL:AEV85618.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00926038,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00926160,
KW   ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     13     36       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    185    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      206    258       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      280    494       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   497 AA;  54613 MW;  6C1B2CA79DF99284 CRC64;
     MIYRAGVWNT QRWFASVLVA MVVLVLGASV VGAHLLNRTA AVSNRLSDRI SPARTAVVQL
     DGALREQEAA VHGFLLSGVT DFADSYQQAV GAERQDEARL RELIDDQPAA LADLTAVEEQ
     AATWRATVAE PLMQAATTGT GDAVRARAAF TSVRTRLTDL DNRLVGARAA GRDALSESRR
     IRDDVFLTLI GGLLLFIVAI GVLLRLIVLG PLARLGGEVR RVAGGDFEHR VTPRGPADVV
     ALGHDVEAMR ERLADALAES RQQQVTLSRV NADLEQFAYV ASHDLQEPLR KVASFCQMLQ
     RRYGEILDER GRRYVEFAVD GATRMQRLIN DLLTFSRIGR VYDGWEPIDL NTVLDRAEDA
     LAITIGETGA QIVRPQLPTV PGDSTLLSML WQNLISNAVK FRHPDRTPRV EITVEPDGDL
     WAFTVTDNGI GIDASYADKI FVIFQRLHQR DAYPGTGIGL AICKKVTEFH GGTIALDPEH
     RDGARFVVTL RRDRAGE
//
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