ID G8TVS5_SULAD Unreviewed; 1034 AA.
AC G8TVS5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Sulac_1271 {ECO:0000313|EMBL:AEW04769.1};
OS Sulfobacillus acidophilus (strain ATCC 700253 / DSM 10332 / NAL).
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Clostridiales Family XVII. Incertae Sedis; Sulfobacillus.
OX NCBI_TaxID=679936 {ECO:0000313|EMBL:AEW04769.1, ECO:0000313|Proteomes:UP000005439};
RN [1] {ECO:0000313|Proteomes:UP000005439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700253 / DSM 10332 / NAL
RC {ECO:0000313|Proteomes:UP000005439};
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Chertkov O.,
RA Saunders E., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R.,
RA Gehrich-Schroeter G., Schneider S., Klenk H.-P., Eisen J.A.;
RT "The complete genome of chromosome of Sulfobacillus acidophilus DSM
RT 10332.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEW04769.1, ECO:0000313|Proteomes:UP000005439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700253 / DSM 10332 / NAL
RC {ECO:0000313|Proteomes:UP000005439};
RX PubMed=23407703; DOI=10.4056/sigs.2736042;
RA Anderson I., Chertkov O., Chen A., Saunders E., Lapidus A., Nolan M.,
RA Lucas S., Hammon N., Deshpande S., Cheng J.F., Han C., Tapia R.,
RA Goodwin L.A., Pitluck S., Liolios K., Pagani I., Ivanova N., Mikhailova N.,
RA Pati A., Palaniappan K., Land M., Pan C., Rohde M., Pukall R., Goker M.,
RA Detter J.C., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Mavromatis K.;
RT "Complete genome sequence of the moderately thermophilic mineral-sulfide-
RT oxidizing firmicute Sulfobacillus acidophilus type strain (NAL(T)).";
RL Stand. Genomic Sci. 6:1-13(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP003179; AEW04769.1; -; Genomic_DNA.
DR AlphaFoldDB; G8TVS5; -.
DR STRING; 679936.Sulac_1271; -.
DR KEGG; sap:Sulac_1271; -.
DR PATRIC; fig|679936.5.peg.1332; -.
DR HOGENOM; CLU_001600_4_0_9; -.
DR Proteomes; UP000005439; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:AEW04769.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005439};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEW04769.1}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1034 AA; 115930 MW; 12C6AB0824FA023F CRC64;
MAGLSAHLHV HSAFSFLNGA SMPEDLVAEA ARQGIEVLAL TDSDRVSGVV AFLKACEEYG
IKGLVGAEVT VEEAGKLILL APDTEGYTRL NRLLTEAHLS SPRGAPRVSW DVLDTWGPGL
VGLTGDREGI LARAWLKGRR DTIEDLARRL QRSLAGRVYI ELTASLLPGD RLLFRALGDI
GQALGIPLVV TAAAHYARKQ DFGLFDLMTC IRLGQPVEAV SPERRLNAEN YLKPWSMLAQ
TFRAWPEALA TTRQLAETLQ TPDILTRRYP PGFSLPDGVT ADAYLRHWVR QGAKWRYRER
WHTVWPRIRH ELEVISRLGY AEYFLVVWDV ARYARRQGIR FSGRGSAADS VVAYVLGITD
VDAYARQLLF ERFMSPERQE APDIDIDFDA RYRDQIEAYV VERYGQDHVA RVATYQTYRP
RLAVREIGKV LGYPPAELDA LAKSLPEMPI TAILEHWDDI PELRQYADAD RLRQVLAWAQ
KITGKPRHLG THLGGVVISQ RPLAEIGPRE RSAKEVEIMP FDKRDIETLG LMKLDLLSLR
IFSAVDIAQK HIQSEQPAFD YDRIPLTDDQ TYQRLARGEG VGVFQLESPA QRALAQRLKP
DTWEDIVASL ALIRPGPIKG NMVDPFVARR RGYEPVTYLL PELEPILKKT YGVILFQEQV
IAIASRIAGF TPGEADALRR VMTHARSPEE MAAIGDRFRA KAEARGIDPV TAQALFQQIA
GYASYGFNEA HAAAFAETAY RTAYLLEHYP VAYFVGLLNA EPLGYYPIDI LLVEARRRGV
TIRPLDINHS QVDVVPEEGT IRLGFRLVKG LGRSEAECLV ARRPPGGYRH PEEVIERSCL
SMDQLIPLIH VGAFDAINPD RVGLLQDIAG PNALQLSEAR PERRPVLAQR LAADYRYLGF
GQETQWMALW RTKLVQQGFL TVAEVLQKPP GTPVRLVAMI YRPHRPPTRS GKIVVFLSLW
DETGLLEAHL PPEGYQQYGH LLFGGKAVRV VALSGTRQPG GMGIRHLAPW PPETTTENLQ
NLSREFRQNK QENS
//
