ID G8U071_SULAD Unreviewed; 946 AA.
AC G8U071;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=2-oxoglutarate dehydrogenase E1 component {ECO:0000313|EMBL:AEW05320.1};
DE EC=1.2.4.2 {ECO:0000313|EMBL:AEW05320.1};
GN OrderedLocusNames=Sulac_1827 {ECO:0000313|EMBL:AEW05320.1};
OS Sulfobacillus acidophilus (strain ATCC 700253 / DSM 10332 / NAL).
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Clostridiales Family XVII. Incertae Sedis; Sulfobacillus.
OX NCBI_TaxID=679936 {ECO:0000313|EMBL:AEW05320.1, ECO:0000313|Proteomes:UP000005439};
RN [1] {ECO:0000313|Proteomes:UP000005439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700253 / DSM 10332 / NAL
RC {ECO:0000313|Proteomes:UP000005439};
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Chertkov O.,
RA Saunders E., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R.,
RA Gehrich-Schroeter G., Schneider S., Klenk H.-P., Eisen J.A.;
RT "The complete genome of chromosome of Sulfobacillus acidophilus DSM
RT 10332.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEW05320.1, ECO:0000313|Proteomes:UP000005439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700253 / DSM 10332 / NAL
RC {ECO:0000313|Proteomes:UP000005439};
RX PubMed=23407703; DOI=10.4056/sigs.2736042;
RA Anderson I., Chertkov O., Chen A., Saunders E., Lapidus A., Nolan M.,
RA Lucas S., Hammon N., Deshpande S., Cheng J.F., Han C., Tapia R.,
RA Goodwin L.A., Pitluck S., Liolios K., Pagani I., Ivanova N., Mikhailova N.,
RA Pati A., Palaniappan K., Land M., Pan C., Rohde M., Pukall R., Goker M.,
RA Detter J.C., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Mavromatis K.;
RT "Complete genome sequence of the moderately thermophilic mineral-sulfide-
RT oxidizing firmicute Sulfobacillus acidophilus type strain (NAL(T)).";
RL Stand. Genomic Sci. 6:1-13(2012).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP003179; AEW05320.1; -; Genomic_DNA.
DR AlphaFoldDB; G8U071; -.
DR STRING; 679936.Sulac_1827; -.
DR KEGG; sap:Sulac_1827; -.
DR PATRIC; fig|679936.5.peg.1892; -.
DR HOGENOM; CLU_004709_1_0_9; -.
DR Proteomes; UP000005439; Chromosome.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd02016; TPP_E1_OGDC_like; 1.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR HAMAP; MF_01169; SucA_OdhA; 1.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR023784; 2oxoglutarate_DH_E1_bac.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR Pfam; PF00676; E1_dh; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AEW05320.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005439};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 592..787
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
FT REGION 911..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 105573 MW; 72468F0FD7D4D997 CRC64;
MDTQQVFEWF VGPNLGYLAE AYERYRNDPD SVDPETRALI EQLDPAWWER WLGGETTAQP
VAGPTTTIPT EKIVKAVQLA RTIREFGHLQ ASFDPLGVSP RKVVDDPEVM GITDNDLAQM
PATVVWPRGL RQAPNALEAV KILRQVYSGP LGYDFSHVHN FDERDWLRQQ VEGGGLTVSF
SPEEKRALLF RLTEVEGFER FLHTTFPGQK RFSIEGTDML VPMLDSLIAQ AVKQGIHEVT
IGMAHRGRLN VLAHILGKPY EKIFSEFHSA PNKELVPSEG SMGINAGWTG DVKYHLGAHK
LLRDGELSGA RITLANNPSH LEFVNPVIQG ATRAAQEDTR HPGQPSLEVD RAMAIAIHGD
ASFPGEGIVA ETLNLSRLAG YHTGGTVHII MNNGLGFTTG PEEGRSTLYA SDLAKGYEIP
VVHVNADDPM ACLLAVQLAF EYRQRFHKDF LIDLVGYRRW GHNEGDEPAY TQPVLYQKIA
RHPTVRALFA DRLVSEGIVT PEEVQEMAGQ VHARLVEAKD RVQDGVIPPD EPEPSTWSDA
LIALAEPTAV DADELIRLAR EAHQWPEAFH PNPKLARQLQ RRLDNLTEPN GIDWGLAETL
AFASILAEGT PIRLSGQDSE RGTFSQRHLV LHDVDTNQKY TPLQHLPSAR ASFAVYNSPL
SEAAVLGFEY GYNVEAPTVM TLWEAQFGDF ANAAQVIIDQ FLSAARAKWK ERSGLVLLLP
HGYEGQGPEH SSARLERYLQ LAADNNMRIA NCTTAAQYFH LLRQQSHLLR RDPRPLVIMT
PKSLLRHPLA ASSLHDLSHG RFQPVLEHEA AKEHPESIER VILLSGKVVV DVLTRLGGHV
PEHVSIIRLE QLYPFPDGEI EAIFHRYPNL TDVVWLQEEP RNMGAWRYIQ PRLEAHLPPG
RTLRYAGRPE RAATAEGFPE MHEEEQGRIV QDALGESKVS TQGGHR
//
