ID G8Y7Q0_PICSO Unreviewed; 728 AA.
AC G8Y7Q0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Piso0_004182 protein {ECO:0000313|EMBL:CCE84630.1};
GN Name=Piso0_004182 {ECO:0000313|EMBL:CCE84630.1};
GN ORFNames=GNLVRS01_PISO0K11252g {ECO:0000313|EMBL:CCE83599.1},
GN GNLVRS01_PISO0L11253g {ECO:0000313|EMBL:CCE84630.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE84630.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|EMBL:CCE84630.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
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DR EMBL; FO082049; CCE83599.1; -; Genomic_DNA.
DR EMBL; FO082048; CCE84630.1; -; Genomic_DNA.
DR AlphaFoldDB; G8Y7Q0; -.
DR STRING; 559304.G8Y7Q0; -.
DR eggNOG; KOG3589; Eukaryota.
DR HOGENOM; CLU_024143_0_0_1; -.
DR InParanoid; G8Y7Q0; -.
DR Proteomes; UP000005222; Chromosome K.
DR Proteomes; UP000005222; Chromosome L.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10845; REGULATOR OF G PROTEIN SIGNALING; 1.
DR PANTHER; PTHR10845:SF192; RGS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 323..410
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 468..604
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 694..724
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 609..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 83021 MW; 4AC414DF87E83689 CRC64;
MWSVDTTTML MGPISKKMKR ITGDNEPIRT PATTKSTRTL HETVLKNFNR TPSGKIYEKD
IKDIYSMMLL CLRLQESNGS KRRLNYFFKN HAFTFHVNDA VQALNDLTVS IDLSRVTTVI
SYSIKPELGT ALVKKFFAAK LLHCPTDRTR SKPKQGVLLQ PTPKGVALLE DFYRNIGGTR
EKVPEILLST LNSMELFKFE RDPITDKILY SDYLLQLFFK KLVGKYPNVW SPHDKPDKLP
NIETKLDLND NNDFCPRSAD KVNINLQHIL EGVAIETTSN DDNFSDSCNS RKFTTCDHNC
HSPLHHRYFT NPDSDSHVQY YVSDSGIKFH RNKIFTNHNG EKVAIKYCIS GKALCQWICD
CTDILNISHA IKICDLLLTA RYFSPITLYP SNAAIDRFAP SRDSFYILTK TGLDVLEWNI
DSDVMERNPS YSLGNEEHQS QNAVYLPDVM GDLQEQSCKQ NYDTSTMSLK ESLKDPGTRY
LFKKHLESEF CAENLEAYLQ LKQFGKRMKV LDRLLSLKSL DNLETSKSLD IQINQLVDAS
LALVYKIYFT YFSSDAPFLL NVDYNLKKQI SGILVKSENS ANLREGERGS FPIEHSPAFS
EFVDREDKLD SNSDLPASIS SDENPFATPP PSSHSSACDP CKFGDELEIQ FELSETHTYA
ENKGDLLYSS SNLSSVFGER LSRLLDLLLQ ISVLYNQASV DIFRLMEIDS FPKFLKSNMH
DELWSQNS
//
