ID G8Y9J6_PICSO Unreviewed; 834 AA.
AC G8Y9J6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=beta-glucosidase {ECO:0000256|ARBA:ARBA00012744, ECO:0000256|RuleBase:RU361161};
DE EC=3.2.1.21 {ECO:0000256|ARBA:ARBA00012744, ECO:0000256|RuleBase:RU361161};
GN Name=Piso0_004713 {ECO:0000313|EMBL:CCE84110.1};
GN ORFNames=GNLVRS01_PISO0K22934g {ECO:0000313|EMBL:CCE84110.1},
GN GNLVRS01_PISO0L22935g {ECO:0000313|EMBL:CCE85141.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE84110.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|EMBL:CCE84110.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-glucosyl residues
CC with release of beta-D-glucose.; EC=3.2.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000448,
CC ECO:0000256|RuleBase:RU361161};
CC -!- PATHWAY: Glycan metabolism; cellulose degradation.
CC {ECO:0000256|RuleBase:RU361161}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC {ECO:0000256|ARBA:ARBA00005336, ECO:0000256|RuleBase:RU361161}.
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DR EMBL; FO082049; CCE84110.1; -; Genomic_DNA.
DR EMBL; FO082048; CCE85141.1; -; Genomic_DNA.
DR AlphaFoldDB; G8Y9J6; -.
DR STRING; 559304.G8Y9J6; -.
DR eggNOG; ENOG502QR4D; Eukaryota.
DR HOGENOM; CLU_004542_4_0_1; -.
DR InParanoid; G8Y9J6; -.
DR OMA; YCSENSD; -.
DR UniPathway; UPA00696; -.
DR Proteomes; UP000005222; Chromosome K.
DR Proteomes; UP000005222; Chromosome L.
DR GO; GO:0008422; F:beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102483; F:scopolin beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR026891; Fn3-like.
DR InterPro; IPR019800; Glyco_hydro_3_AS.
DR InterPro; IPR002772; Glyco_hydro_3_C.
DR InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR PANTHER; PTHR42715; BETA-GLUCOSIDASE; 1.
DR PANTHER; PTHR42715:SF28; BETA-GLUCOSIDASE-RELATED; 1.
DR Pfam; PF14310; Fn3-like; 1.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR Pfam; PF01915; Glyco_hydro_3_C; 1.
DR Pfam; PF07691; PA14; 1.
DR PRINTS; PR00133; GLHYDRLASE3.
DR SMART; SM01217; Fn3_like; 1.
DR SMART; SM00758; PA14; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
DR PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
DR PROSITE; PS51820; PA14; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU361161};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361161};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361161};
KW Polysaccharide degradation {ECO:0000256|RuleBase:RU361161};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222}.
FT DOMAIN 397..558
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
SQ SEQUENCE 834 AA; 92241 MW; 038EF115298D51BD CRC64;
MGEFDIEQVL SQLTLHEKIS LLSGIDFWHT FPVHRLDIPS LRFSDGPNGV RGTKFFNGVP
SACFPCGTAL ASTFDKQLLL DIGRLMGEEA IHKSVHVVLG PTTNMQRGPL GGRGFESFSE
DPYLAGMASA SIINGIQDKK VAATIKHFVG NDLEDQRNSS NSIITERALR EIYLEPFRIA
VKLSNPMAVM TGYNRLNGEH VSQSEKLLQD ILRDEWKWDG TIMSDWFGTY STKEALANGL
DIEMPGPTRF RNPDPVAHSV NTKELHSKVI DERARNVLKL IKYTKMLNLP ENGPESDSNN
TPQTQKLLKE VAADSIVLLK NEDVLPLNKN SSIAVIGPNA KYAAYCGGGS AALRSYYSVT
PFEGIAKKMT SSPKYALGAM GVKSLQGLAE NLTNPFTGKR GYNMKFFKEP SSSSHRELVD
ELNLDLSHVF LADYKNPKLD SNLYFIDFEG DLVVNESGEY AFGISVYGTA QLFVDGKLLV
DNKTSQSRGD SFFNSGTSEK KGTIFLEKGK EYKIRVEFGS APSYTLVNAG VVEFGGGGGV
NLGFSKVYEK DEEIKKAVEV AKSVDNVVLC IGLNQEWESE SFDRPDMNLP PNTDELVEAV
INANPNTIVV NQSGTPVELP WVSKAKGLIQ AWFGGNELGN ALADVLFGDT NPSGKLSLSF
PKVLEDNPTY LNFKTEMGRV LYGEDIYIGY RFYQKMRRDV AFPFGFGLSY TSFGYSDLNI
ELSEDKLDVT IKVKNNGPYK GKDVPQLYIS ALNSAVSRPV RELKGFEKIE LESGESTLVH
FDLPLKECIS YFDEYMNQWC AEAGAYTVEI GKSSEDIVLH SDFAVKETTY WLGA
//
